Somatostatin cells regulate sensory response fidelity via subtractive inhibition in olfactory cortex

Nature Neuroscience
James F Sturgill, Jeffry S Isaacson

Abstract

Diverse types of local GABAergic interneurons shape the cortical representation of sensory information. Here we show how somatostatin-expressing interneurons (SOM cells) contribute to odor coding in mouse olfactory cortex. We find that odor-tuned SOM cells regulate principal cells through a purely subtractive operation that is independent of odor identity or intensity. This operation enhances the salience of odor-evoked activity without changing cortical odor tuning. SOM cells inhibit both principal cells and fast-spiking interneurons, indicating that subtractive inhibition reflects the interplay of multiple classes of interneurons.

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Citations

Sep 1, 2015·Trends in Neurosciences·Camille AlleneAlberto Bacci
Oct 21, 2015·Frontiers in Neural Circuits·Li ShenBo Hong
Sep 25, 2015·Neuron·Bryan A SeyboldAndrea R Hasenstaub
Apr 26, 2016·Nature Neuroscience·Kwang Woo KoNace L Golding
Oct 18, 2016·Frontiers in Neural Circuits·Iryna Yavorska, Michael Wehr
Jul 4, 2019·Nature Communications·Duje TadinRandolph Blake
Jun 26, 2020·Journal of Neurophysiology·Miaomiao Jin, Lindsey L Glickfeld
Mar 7, 2020·Frontiers in Neuroscience·Daniel Saiz-SanchezAlino Martinez-Marcos
Aug 9, 2018·Proceedings of the National Academy of Sciences of the United States of America·Adam M LargeAnne-Marie M Oswald
Sep 2, 2016·Frontiers in Neural Circuits·Adam M LargeAnne-Marie M Oswald
Apr 27, 2019·Frontiers in Behavioral Neuroscience·Sonia NoceraCécile Viollet
Jan 5, 2021·Frontiers in Cellular Neuroscience·Jun WangHan Xu
Oct 16, 2020·ACS Chemical Neuroscience·Grazyna LietzauCesare Patrone
Dec 17, 2021·ELife·Shivathmihai Nagappan, Kevin M Franks

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Software Mentioned

AxographX
Matlab
UltraMegaSort2000

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