Somatostatin imaging of neuroendocrine-differentiated prostate cancer

Clinical Nuclear Medicine
Thomas A HopeCharles J Ryan

Abstract

After prolonged androgen deprivation therapy, a subset of castrate-resistant prostate cancer patients will develop neuroendocrine prostate cancer (NEPC) associated with resistance to further hormonal therapy and frequent visceral metastases. Imaging the presence of somatostatin receptors on the cancer cell surface may provide a readily available, noninvasive means to distinguish adenocarcinoma from NEPC. This distinction is important for therapeutic decision making and may open the door for developing novel radionuclide targets for the treatment of this aggressive subtype of prostate cancer. We describe a case of NEPC successfully imaged using In-labeled octreotide.

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Citations

Aug 3, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Sara SheikhbahaeiSteven P Rowe
Sep 24, 2020·Abdominal Radiology·Pankaj NepalVijayanadh Ojili
Jun 9, 2017·Molecular Cancer Research : MCR·Rahul AggarwalMichael J Evans
Jan 13, 2021·Current Oncology Reports·Yasutaka Yamada, Himisha Beltran

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