Somatostatin in lungfish kidney: an immunohistochemical, autoradiographical and in situ hybridisation study

General and Comparative Endocrinology
M A MasiniB M Uva

Abstract

The localisation of somatostatin-14 (SST-14) was examined immunohistochemically using the antibody Ab-SST-14 in the kidney of the African lungfish Protopterus annectens. Immunoreactive cells were present in the proximal tubules. In situ hybridisation, using an oligonucleotide probe complementary to mRNA for SST-14 and labeled at the 3'-end with alpha-35S, showed SST-14 mRNA distributed in cells with the same localisation as seen for SST-14 immunoreactive cells. Binding sites for SST-14 were identified with autoradiography using 125I SST-14. Binding sites were concentrated on cells of the proximal tubules. It is suggested that SST-14 may be synthesised in the lungfish mesonephros.

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Citations

May 3, 2005·General and Comparative Endocrinology·Laura E Nelson, Mark A Sheridan
Dec 26, 2001·The Journal of Experimental Zoology·Maddalena SturlaUva Bianca Maria
May 17, 2006·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·José L OjedaYuen K Ip

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