Somatostatin-induced histamine secretion in mast cells. Characterization of the effect

European Journal of Pharmacology
T C TheoharidesW W Douglas

Abstract

Somatostatin, in concentrations up to 100 ng/ml, had no effect on mast cell secretion induced either by compound 48/80 or by the ionophore A23187. In higher concentration somatostatin induced mast cell secretion. Light and electron microscopic observations showed that the secretory response was identical with that induced by 48/80 and involved extrusion of secretory granules by exocytosis. As with 48/80, this response to somatostatin was inhibited by treating the mast cells with EDTA or EGTA or by exposing them briefly to A23187 in calcium-free media, all of which procedures seemingly deplete cellular calcium stores. Reintroduction of calcium (but not magnesium), restored secretory responsiveness. Somatostatin-induced secretion further resembled that induced by 48/80 or A23187 in its intensity, rapid time course, and dependence on albumin. Pretreatment of mast cells with dibutyryl cyclic AMP or 8-bromo cyclic AMP substantially reduced the secretory responses to both somatostatin and 48/80 but had little effect on the response to A23187. Somatostatin, like 48/80, lowered intracellular cyclic AMP levels in a time and dose-dependent fashion. Finally, as earlier found for 48/80, somatostatin attached to Sepharose columns retarded t...Continue Reading

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Citations

Dec 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·W Piotrowski, J C Foreman
Mar 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·G SkofitschF Lembeck
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Jul 17, 1981·European Journal of Pharmacology·T C Theoharides, W W Douglas
Jan 1, 1986·Annals of the New York Academy of Sciences·D van der Kooy
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Aug 5, 2018·The Journal of Pharmacology and Experimental Therapeutics·Erifili HatziagelakiTheoharis C Theoharides
Oct 1, 1981·Biochemical Pharmacology·T C TheoharidesW W Douglas
Jan 15, 1983·Biochemical Pharmacology·N D TsakalosP W Askenase

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