Somatostatin inhibits tooth-pulp-evoked rat cervical dorsal horn neuronal activity

Experimental Brain Research
M TakahashiShigeji Matsumoto

Abstract

The aim of the present study is to investigate the effect of somatostatin (SST). It is well known that SST is a neuromodulator in the central nervous system and is involved in the regulation of metabolic and neuroendocrine functions. Recent experimental and clinical findings indicate a role for SST in the central processing of nociception. Therefore, we tested the hypothesis whether a local release of SST modulates the tooth-pulp (TP)-evoked upper cervical spinal dorsal horn (C(1)) neuronal activity, using microiontophoretic application and immunohistochemical techniques. Extracelluar single unit recordings were made from 35 C(1) neurons responding to TP electrical stimulation (TPS) in pentobarbital anesthetized rats. Microiontophoretic application of SST (30-70 nA) current dependently inhibited TP-evoked C(1) neuronal discharges (60%, 21/35). The inhibition of this discharge by 50 nA SST application was abolished by co-application of a SST(2) receptor antagonist (Cyanamid-154806, 50 nA). Immunoreactivity for SST(2A) receptor was found in the superficial layer (Iota-IotaIotaIota) of C(1) dorsal horn. These results suggest that a local release of SST modulates the TP-evoked C(1) neuronal activity and this may contribute to a use...Continue Reading

References

Jun 18, 1991·European Journal of Pharmacology·A EschalierP Duchêne-Marullaz
Nov 1, 1995·Arthritis and Rheumatism·M Matucci-CerinicP Marinelli
Dec 27, 1994·European Journal of Pharmacology·J C ReubiJ A Laissue
Mar 1, 1995·Trends in Pharmacological Sciences·D HoyerJ E Taylor
Aug 6, 1999·Frontiers in Neuroendocrinology·Y C Patel
Jun 1, 2000·Regulatory Peptides·I SelmerP C Emson
Feb 22, 2003·Naunyn-Schmiedeberg's Archives of Pharmacology·Massimo Dal MontePaola Bagnoli
Aug 5, 2003·Neuroscience·H IchikawaT Sugimoto
Feb 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marie-Hélène BassantPascal Dournaud
Jun 13, 2006·Pharmacology & Therapeutics·Erika PintérJános Szolcsányi

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