PMID: 12766068May 27, 2003Paper

Somatostatin is an immunosuppressive factor in aqueous humor

Investigative Ophthalmology & Visual Science
A Taylor, David G Yee

Abstract

To detect the presence of somatostatin (SOM) in normal aqueous humor and to characterize its immunosuppressive activity. Fresh rabbit aqueous humor was assayed for SOM by competitive ELISA. Primed T cells stimulated through their T-cell receptor (TCR) were treated with SOM at concentrations that ranged the level of SOM found in normal aqueous humor. The T cells were assayed for proliferation, lymphokine production, and immunosuppressive activity. Normal rabbit aqueous humor contained 196 +/- 45 pg/mL (10(-10) M) of SOM. At concentrations between 10 and 300 pg/mL, SOM suppressed IFN-gamma production by TCR-stimulated primed T cells in culture. Frozen and thawed aqueous humor depleted of SOM no longer suppressed IFN-gamma production by the TCR-stimulated primed T cells. SOM induced TGF-beta but not IL-4 production, nor did it suppress proliferation by TCR-stimulated primed T cells. The SOM-treated T cells functioned as regulatory T cells, and this regulatory activity was neutralized by anti-alpha-MSH antibodies. Furthermore, SOM induced alpha-MSH production by the TCR-stimulated primed T cells. SOM is present in aqueous humor and contributes to the immunosuppressive activity of aqueous humor. Moreover, SOM induces the production ...Continue Reading

Citations

Jan 13, 2009·Eye·A W Taylor
Mar 22, 2006·Nature Immunology·Jerry Y Niederkorn
Feb 28, 2008·Journal of Glaucoma·Franz H GrusNorbert Pfeiffer
Jan 25, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Joshua T MorganPaul Russell
Feb 24, 2016·Frontiers in Immunology·Andrew W Taylor
Jul 1, 2009·Progress in Retinal and Eye Research·Jerry Y Niederkorn
Feb 2, 2013·The Journal of Investigative Dermatology·Trisia BreitkopfKevin J McElwee
Oct 6, 2007·American Journal of Ophthalmology·Tom MissottenP Martin van Hagen
Jul 29, 2006·Brain Research Reviews·Josef TrogerEduard Schmid
Jun 13, 2006·Molecular and Cellular Endocrinology·Sikha GhoshMiguel Coca-Prados
Dec 12, 2003·Nature Reviews. Immunology·J Wayne Streilein
Feb 13, 2018·Journal of Leukocyte Biology·Andrew W Taylor, Tat Fong Ng
Aug 1, 2007·Proteomics. Clinical Applications·Franz H GrusNorbert Pfeiffer
Apr 8, 2010·Ocular Immunology and Inflammation·Kyle C McKenna, Peter W Chen
Feb 5, 2010·Ocular Immunology and Inflammation·Jerry Y Niederkorn, Joan Stein-Streilein
Oct 24, 2019·Breast Disease·Ismini Michail TsagkarakiElias Alexandros Kotteas
Apr 19, 2020·Investigative Ophthalmology & Visual Science·Sudha Neelam, Jerry Y Niederkorn
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takeshi KezukaMasahiko Usui
Sep 21, 2010·Ocular Immunology and Inflammation·Junko HoriSharmila Masli
Sep 16, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ru ZhouRachel R Caspi
Oct 9, 2019·Seminars in Immunopathology·Gerhild Wildner, Maria Diedrichs-Möhring
Nov 26, 2010·Ocular Immunology and Inflammation·Andrew W Taylor, Henry J Kaplan
Jun 13, 2015·The Open Ophthalmology Journal·George L SpaethAna Figueiredo
Jun 1, 2016·Melanoma Management·Dae Won KimSapna P Patel
Nov 26, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alastair K DennistonS John Curnow
Jan 6, 2004·Ocular Immunology and Inflammation·Andrew Taylor
Jan 21, 2021·Toxicologic Pathology·Meg Ferrell RamosSharmila Masli
Oct 28, 2020·International Journal of Molecular Sciences·Ayaka EdoMasayo Takahashi
Jul 15, 2015·The Open Ophthalmology Journal·Rodrigo Bolaños-JiménezYonathan Garfias

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