PMID: 6112180Jun 1, 1981Paper

Somatostatin-like immunoreactivity in human peripheral plasma measured by radioimmunoassay following affinity chromatography

Diabetes
K TsudaH Imura

Abstract

Somatostatin-like immunoreactivity (SLI) concentrations were determined in human peripheral plasma using affinity chromatography followed by radioimmunoassay. In normal subjects, fasting SLI ranged from 2.9 to 22.0 pg/ml with a mean +/- SE value of 10.2 +/- 2.1 pg/ml. In totally pancreatectomized or gastrectomized patients, fasting SLI levels were not different from the values in normal subjects. In patients with medullary thyroid carcinoma, fasting SLI ranged from 11.8 to 71.0 pg/ml with a mean of 29.3 +/- 12.3 pg/ml, which was significantly higher than normal values (P less than 0.01). Following meal ingestion, plasma SLI increased significantly in normal subjects from a basal level of 9.1 +/- 2.1 pg/ml to a peak value of 15.4 +/- 2.9 pg/ml (P less than 0.02). These results indicate that radioimmunoassay combined with affinity chromatography provides an accurate method of measuring SLI in human plasma.

Citations

Jun 1, 1982·Regulatory Peptides·L Hilsted, J J Holst
May 1, 1989·The Journal of Clinical Investigation·J W EnsinckB H Francis
May 10, 2015·Pharmacology & Therapeutics·Uma RaiSimon A Young
Sep 1, 1988·Pathology, Research and Practice·K Kamijo, A Yachi
Jan 1, 1984·Acta Physiologica Scandinavica·P G BurholJ Florholmen
Jul 1, 1984·Acta Physiologica Scandinavica·P G BurholR Jorde
Dec 30, 1986·Biochemical and Biophysical Research Communications·H FukumotoH Imura

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.