Somatostatin-like immunoreactivity in primary afferents of the medial articular nerve and colocalization with substance P in the cat

The Journal of Comparative Neurology
U HaneschR F Schmidt

Abstract

The proportion of somatostatin-containing dorsal root ganglion cells innervating the knee joint of the cat via the medial articular nerve was determined by using retrograde labeling with fast blue and immunohistochemistry. Immunoreactivity was found in 8.6% of labeled cell bodies. In colchicine-treated ganglia, the proportion increased to 16.8%. Only small and intermediate-sized perikarya showed somatostatin-like immunoreactivity, indicating that this neuropeptide is synthesized predominantly in primary afferent units with unmyelinated sensory axons but may also be present in primary afferents with thinly myelinated sensory fibers. Colchicine treatment had no influence on the cell size distribution. Colocalization of somatostatin with substance P was determined by comparing the proportions of immunopositive dorsal root ganglion cells after incubation with antibodies against substance P or somatostatin or with a mixture of both. Substance P-like immunoreactivity was found in 18.1% (untreated ganglia) and 19.6% (colchicine treated ganglia) of the labeled neurons. After incubation with a mixed antibody solution, 18.2% of joint afferents in untreated and 19.9% of the cells in colchicine-treated ganglia were immunopositive. Comparin...Continue Reading

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Citations

May 21, 2011·Clinical and Experimental Pharmacology & Physiology·Jun WangYan Zhao
Jun 30, 2016·Anatomia, histologia, embryologia·A DudekJ Kaleczyc
Oct 1, 2008·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Sung Jun JungSeog Bae Oh
Sep 6, 2020·Clinical and Experimental Pharmacology & Physiology·Thomas S W ParkMaree T Smith

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