PMID: 9523593Apr 2, 1998Paper

Somatostatin potently stimulates in vivo striatal dopamine and gamma-aminobutyric acid release by a glutamate-dependent action

Journal of Neurochemistry
G J HathwayK M Kendrick

Abstract

We have used in vivo microdialysis in anaesthetised rats to investigate whether somatostatin (SRIF) can play a neuromodulatory role in the striatum. When 100 nM SRIF was retrodialysed for 15 min, it increased concentrations of dopamine (DA) by 28-fold, gamma-aminobutyric acid (GABA) by eightfold, and glutamate (Glu) by sixfold as well as those of aspartate (Asp) and taurine (Tau). These effects were both calcium- and tetrodotoxin-sensitive. Lower (10 or 50 nM) and higher (1 microM) SRIF concentrations were less effective. Rapid sampling showed that whereas Asp and Glu concentrations were raised for 3 min at the start of 15-min SRIF infusions, those of DA were increased for 12 min. A second 15-min application of 100 nM SRIF given 135 min after the first application failed to increase transmitter release. An NMDA receptor antagonist, 2-amino-5-phosphonopentanoic acid (200 microM), blocked SRIF (100 nM)-evoked Asp, Glu, Tau, and GABA release and reduced that of DA. An alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate antagonist, 6,7-dinitroquinoxaline-2,3-dione (100 microM), blocked SRIF-induced DA and Tau release and reduced that of Asp, Glu, and GABA. These results show that SRIF increases DA, Glu, Asp, GAB...Continue Reading

Citations

Dec 1, 1999·British Journal of Pharmacology·G J HathwayK M Kendrick
May 5, 2000·Experimental Physiology·K M Kendrick
Apr 16, 2010·The Journal of Comparative Neurology·Gabriel LepousezCécile Viollet
Oct 13, 2012·Journal of Pharmacological Sciences·Hiroko IkedaAlexander R Cools
Nov 15, 2013·Alcoholism, Clinical and Experimental Research·Susanne JonssonBo Söderpalm
Nov 13, 2001·British Journal of Pharmacology·G J HathwayK M Kendrick
Jul 19, 2005·The Journal of Comparative Neurology·María Gutièrrez-MecinasFrancisco José Martínez-Guijarro
Jun 1, 2000·Regulatory Peptides·I SelmerP C Emson
Nov 9, 2005·Pharmacology & Therapeutics·Kyriaki ThermosDaniel Hoyer

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