Somatostatin receptor profiling in hepatic metastases from small intestinal and pancreatic neuroendocrine neoplasms: immunohistochemical approach with potential clinical utility

Cancer Control : Journal of the Moffitt Cancer Center
Aejaz NasirLarry K Kvols

Abstract

The expression of somatostatin receptors (SSTRs) on endocrine tumor (ET) cells forms the basis for somatostatin analog treatment of patients with SSTR-positive, hormonally active ETs. In patients with SSTR-negative ETs, the clinical response is generally absent or suboptimal, while nonfunctioning ETs with SSTR positivity show a variable response to such therapy. We retrospectively studied SSTR subtype expression in hepatic metastases from 14 adult patients with primary endocrine carcinomas (ECAs) of the small intestine and pancreas and compared SSTR subtype expression among the primary and metastatic ECAs. Polyclonal antibodies against the 5 SSTR subtypes were used on formalin-fixed, paraffin sections from each primary and metastatic ECA. Both qualitative and semiquantitative evaluation of the stained ECA sections was carried out. Eleven (61%) of 18 hepatic metastases from small intestinal and pancreatic ECAs were positive for SSTR-1, 15 (83%) for SSTR-2, 13 (72%) for SSTR-3, 10 (56%) for SSTR-4, and 15 (83%) for SSTR-5. Among 11 hepatic ECA metastases from small intestinal ECAs (carcinoids), 7 (63%) expressed SSTR-1, 9 (81%) expressed SSTR-2, 8 (72%) expressed SSTR-3, 6 (54%) expressed SSTR-4, and 10 (91%) expressed SSTR-5. Of...Continue Reading

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Citations

Nov 7, 2009·Journal of Cellular and Molecular Medicine·Robert Y Osamura
Apr 25, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Levent KabasakalBedii Kanmaz
Nov 11, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anne CouvelardPhilippe Ruszniewski
Nov 29, 2007·Current Opinion in Oncology·Steven B GoldinMonika M Wahi
Jun 10, 2010·Folia Histochemica Et Cytobiologica·Hanna PisarekKatarzyna Winczyk

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