Somatostatin receptor scintigraphy using 99mTc-EDDA/HYNIC-TOC in patients with medullary thyroid carcinoma

European Journal of Nuclear Medicine and Molecular Imaging
Rafał CzepczyńskiAlberto Signore


Several new somatostatin analogues have been developed for the diagnosis and therapy of different tumours. Since somatostatin receptors are often over-expressed in medullary thyroid carcinoma (MTC), the aim of our study was to evaluate the utility of scintigraphy with the somatostatin analogue (99m)Tc-EDDA/HYNIC-TOC in MTC in comparison with other diagnostic techniques. Forty-five patients with MTC, aged 14-83 years, were investigated. Scintigraphy using (99m)Tc-EDDA/HYNIC-TOC (Tektrotyd) was performed 2 and 4 h post injection of 740 MBq (20 mCi) of the tracer. Other imaging techniques were also applied and analysed in individual cases (ultrasonography, computed tomography, (99m)Tc(V)-DMSA, (131)I-MIBG, (99m)Tc-MDP, (111)In-DTPA-octreotide and (18)F-FDG-PET) and compared with (99m)Tc-EDDA/HYNIC-TOC. In group 1 (eight patients before thyroidectomy), uptake of the tracer was found in the primary tumours. In group 2 (six patients with remission), a false positive result was found in one patient; in the remaining five patients, no pathological foci were visualised. In group 3 (31 patients with post-surgical hypercalcitoninaemia), scintigraphy was true positive in 23 patients (74.2%): uptake in the thyroid bed was found in five pati...Continue Reading


Oct 1, 1978·American Journal of Clinical Pathology·R A DeLellisH J Wolfe
Apr 1, 1989·Nuclear Medicine Communications·U P GuerraM Bestagno
Jan 1, 1995·Clinical Endocrinology·K Frank-RaueF Raue
Jun 1, 1993·Nuclear Medicine Communications·U DörrH Bihl
Aug 17, 1999·Archives of Otolaryngology--head & Neck Surgery·Q WangS Sone
Jun 15, 2000·European Journal of Nuclear Medicine·K Brandt-MainzA Bockisch
May 25, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Theodosia MainaEfstratios Chiotellis
Jan 9, 2003·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·B SallerK Mann
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Claudia ScolloMartin Schlumberger
Jul 8, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Anna PłachcińskaJacek Kuśmierek
Aug 29, 2003·Current Treatment Options in Oncology·Jeffrey F Moley
Nov 18, 2003·Clinical Endocrinology·Yodphat KrauszOra Israel
Apr 8, 2004·Cancer Biotherapy & Radiopharmaceuticals·Lisa BodeiGiovanni Paganelli
Jun 10, 2004·Cancer Biotherapy & Radiopharmaceuticals·Maria ParisellaAlberto Signore
Jan 7, 2005·The Journal of Clinical Endocrinology and Metabolism·Andreas MachensHenning Dralle
Feb 19, 2005·Journal of Surgical Oncology·Frank J Quayle, Jeffrey F Moley
Mar 29, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Theodosia MainaMarion de Jong
May 25, 2006·European Journal of Nuclear Medicine and Molecular Imaging·A Hubalewska-DydejczykJ Kulig

❮ Previous
Next ❯


Jan 6, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Domenico RubelloMilton D Gross
Apr 11, 2014·International Journal of Endocrinology and Metabolism·Evangelia Skoura
May 29, 2012·Clinical Radiology·K K WongD Rubello
Aug 2, 2012·International Journal of Molecular Imaging·Giorgio TregliaLuca Giovanella
Jun 16, 2009·Journal of Internal Medicine·W van VeelenC J M Lips
Sep 1, 2009·Expert Review of Endocrinology & Metabolism·Cornelis Jm LipsJo Wm Höppener
Jul 1, 2014·Endocrine Reviews·Ka Kit WongMilton D Gross
Oct 17, 2017·EJNMMI Physics·Xinchi HouAnna Celler
Oct 6, 2011·Nuclear Medicine Communications·Jesús Sepúlveda-MéndezOfelia González-Treviño
May 4, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Hao FuLibo Chen
Jul 29, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Joshua GrimesPiotr Zorga

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Nuclear Medicine and Molecular Imaging
Anna PłachcińskaJacek Kuśmierek
Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Armando González-VázquezZohar Gutiérrez-García
Cancer Biotherapy & Radiopharmaceuticals
Maria ParisellaAlberto Signore
© 2021 Meta ULC. All rights reserved