Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines

The Journal of Clinical Endocrinology and Metabolism
K B AinG Venkataraman

Abstract

Somatostatin (SRIH) analogs can suppress the proliferation of human differentiated thyroid carcinoma cell lines that express SRIH receptors (SSTRs) demonstrated by radioligand binding analysis. Five distinct human SSTR subtypes (hSSTR1-5) that bind native SRIH exhibit diverse affinities to a wide range of SRIH analogs. Reverse transcriptase-PCR amplification of ribonucleic acids (RNAs) obtained from normal thyroid tissues and nine human thyroid carcinoma cell lines, grown as monolayer cultures and xenograft tumors in nude mice, were used to discriminate expression of SSTR subtype messenger RNAs (mRNAs). The cell lines were derived from a follicular adenoma (KAK-1), two follicular carcinomas (MRO-87 and WRO-82), two papillary carcinomas (NPA87 and KAT-10), and four anaplastic thyroid carcinomas (DRO-90, ARO-81, KAT-4, and KAT-18). Most thyroid cancer cell line monolayers and xenografts expressed SSTR3 and SSTR5 mRNAs. SSTR1 expression was more varied between monolayers and xenografts, whereas SSTR2 mRNA was only faintly detectable at the most extreme resolution. SSTR4 mRNA was faintly positive in only one anaplastic carcinoma xenograft. Normal thyroid also expressed SSTR3 and SSTR5 mRNAs, with only faint expression of SSTR1 and ...Continue Reading

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Citations

Dec 17, 2009·Thyroid : Official Journal of the American Thyroid Association·Tania PilliBellur S Prabhakar
Jun 12, 2012·Cell and Tissue Research·Caterina SquillaciotiNicola Mirabella
Jul 16, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Tatjana Traub-WeidingerIrene Johanna Virgolini
Feb 28, 2009·Journal of Anatomy·Inés Martín-LacaveEsperanza Conde
Jun 1, 2011·Seminars in Nuclear Medicine·Samuel L RiceJason S Lewis
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May 16, 2013·International Journal of Experimental Pathology·Helen AtkinsonStephen L Atkin
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Jul 15, 1999·The Journal of Clinical Endocrinology and Metabolism·G M VenkataramanK B Ain
Aug 1, 2014·The Journal of Clinical Endocrinology and Metabolism·Katherine B HeidenXiulong Xu

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