PMID: 6125480Jun 15, 1982Paper

Somatostatin-reduced proliferation of murine aplastic carcinoma conditioned to diabetes

International Journal of Cancer. Journal International Du Cancer
S Vuk-PavlovićK Pavelić

Abstract

Murine mammary aplastic carcinoma, when it is passed from one alloxan-diabetic animal to another, after several passages becomes conditioned to hypoinsulinemia by secreting its own substance(s) immunologically cross-reactive with insulin (SICRI). Although not cytotoxic, the total daily dose of 2.5 mg of synthetic linear somatostatin per one kg body mass, administered in three or more portions, retards tumor growth in normoinsulinemic mice and the proliferation of tumors preconditioned by three serial passages in diabetics. After the first passage, somatostatin treatment has no effect on the already slow growth of the unconditioned tumor. Somatostatin-reduced tumor proliferation is accompanied by the strong suppression of insulin and SICRI levels, respectively; this effect is completely abolished by the administration of modest doses of crystalline insulin. It is concluded that somatostatin retards tumor growth by diminution of plasma levels of insulin and SICRI, respectively.

References

Jan 14, 1978·Diabetologia·R LuftT Hökfelt
Apr 1, 1978·The Journal of Endocrinology·C McMartin, G E Purdon
Sep 1, 1980·British Journal of Haematology·K PavelićM Popović
Jul 1, 1981·Cancer·K Pavelić, M Popović
Jan 1, 1980·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·J PavelićK Pavelić

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Citations

Jan 1, 1992·Critical Reviews in Oncology/hematology·R ClarkeM E Lippman

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