PMID: 6107859Nov 6, 1980Paper

Somatostatin selectively inhibits noradrenaline release from hypothalamic neurones

Nature
M Göthert

Abstract

Somatostatin in a hypothalamic peptide hormone which inhibits growth hormone release from the anterior pituitary. However, biochemical and morphological investigations have revealed that somatostatin is located not only in the hypothalamus but also in other brain areas (for example the cerebral cortex) where it occurs and in nerve cell bodies and fibres from which it can be released in a Ca2+-dependent manner. It has therefore been suggested that the neuropeptide may have functions in the central nervous system other than its effect on growth hormone release; one possible action is that of a neuromodulator. Therefore, hypothalamic and cerebral cortical slices of the rat were used to examine whether somatostatin modifies the electrically or CaCl2-evoked release of tritiated monoamines from monoaminergic neurones. it is reported here that somatostatin inhibits 3H-noradrenaline release from the hypothalamus (but not from the cerebral cortex) but does not affect the release of 3H-dopamine and 3H-serotonin.

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Citations

Oct 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·A Tsujimoto, K Morita
Nov 24, 2006·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Feng GaoDongsheng Chen
Dec 8, 1987·Brain Research·X M WangB A Scoggins
Jan 1, 1985·Progress in Neuro-psychopharmacology & Biological Psychiatry·D R RubinowJ C Ballenger
Jan 1, 1988·Progress in Neuro-psychopharmacology & Biological Psychiatry·D R RubinowR M Post
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·L Vécsei, E Widerlöv
Feb 1, 1996·Micron : the International Research and Review Journal for Microscopy·G K Zupanc
Aug 5, 2003·Neuroscience·H IchikawaT Sugimoto
Aug 1, 1991·Journal of Neuroendocrinology·A BenyassiS Arancibia
Aug 1, 1992·Neuropharmacology·A M Mazarati, G Telegdy
Jul 19, 2005·The Journal of Comparative Neurology·María Gutièrrez-MecinasFrancisco José Martínez-Guijarro
Apr 16, 2010·The Journal of Comparative Neurology·Gabriel LepousezCécile Viollet
Mar 8, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·C CalhauI Azevedo
May 16, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·H BönischE Schlicker
Aug 25, 2001·Journal of Medicinal Chemistry·L PoitoutC Thurieau
Apr 1, 1986·Biological Psychiatry·D R Rubinow
Sep 1, 1996·Progress in Neurobiology·M SchindlerP C Emson
Jun 4, 1999·Journal of Medicinal Chemistry·S J HocartD H Coy

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