PMID: 8938725Jan 1, 1996Paper

Somatostatin stimulates BKCa channels in rat pituitary tumor cells through lipoxygenase metabolites of arachidonic acid

Neuropharmacology
K DuersonD L Armstrong

Abstract

The stimulation of large-conductance, calcium-activated (BK) potassium channels by somatostatin through protein dephosphorylation in rat pituitary tumor cells (White et al., Nature 351, 570-573, 1991) is blocked by drugs that interfere with arachidonic acid release by phospholipase A2 and metabolism by 5-lip-oxygenase. In contrast, higher concentrations of the same drugs had no effect on BK channel gating in cell-free patches, on the inhibition of adenylyl cyclase by somatostatin, or on the stimulation of BK channels by protein dephosphorylation through a cGMP-dependent pathway (White et al., Nature 361, 263-266, 1993). Exogenous arachidonic acid (1-20 muM) stimulated BK channel activity through protein dephosphorylation as effectively as somatostatin and was also blocked by inhibitors of lipoxygenases but not by inhibitors of phospholipase A2. These results support the hypothesis that lipoxygenase metabolites of arachidonic acid are second messengers linking pertussis toxin sensitive G-proteins to protein phosphatases regulating potassium channel activity (Armstrong and White, Trends Neurosci. 15, 403-408, 1992).

References

Jan 1, 1979·Methods in Enzymology·A H Tashjian
May 17, 1991·Brain Research·M Ichinose, J H Byrne
Jan 1, 1990·Annual Review of Physiology·D A Brown
Jul 1, 1990·Journal of Neurochemistry·T Shimizu, L S Wolfe
Sep 1, 1990·Trends in Pharmacological Sciences·D Piomelli, P Greengard
Apr 1, 1990·Physiological Reviews·S W Lamberts, R M Macleod
Aug 1, 1988·The Journal of General Physiology·R Horn, A Marty
Sep 1, 1989·British Journal of Pharmacology·R A North
Jan 1, 1994·Annual Review of Physiology·I B Levitan
Jun 1, 1994·Progress in Neurobiology·H Meves
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·L BuscailC Susini
Jul 1, 1993·The Journal of General Physiology·R W SchererG E Breitwieser
Nov 1, 1995·Neuropharmacology·V Y Bolshakov, S A Siegelbaum
Mar 1, 1996·The Biochemical Journal·D B ReardonT W Sturgill

❮ Previous
Next ❯

Citations

Dec 25, 2002·European Journal of Pharmacology·Yen Chin Liu, Sheng Nan Wu
Oct 24, 1998·Trends in Pharmacological Sciences·N W BunnettA De Blasi
Aug 6, 1998·Cellular Signalling·C Sumners, C H Gelband
Jan 4, 2001·Trends in Endocrinology and Metabolism : TEM·M Chinkers
Oct 17, 2008·The Journal of Pharmacology and Experimental Therapeutics·Grzegorz GodlewskiGeorge Kunos
Nov 27, 2009·American Journal of Physiology. Cell Physiology·Juan LiDonald D Denson
Dec 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Liwang Liu, Ann R Rittenhouse
Dec 24, 1997·Nature·C W VaughanM J Christie
Jun 2, 2000·The Journal of Physiology·L Liu, A R Rittenhouse
Jul 22, 2015·Neuropharmacology·Sarah J Lucas, David L Armstrong
Aug 28, 2007·Pharmacology & Therapeutics·Davide Cervia, Paola Bagnoli
Jul 16, 2010·Journal of Cellular and Molecular Medicine·Mehtap CakirAshley Grossman
Dec 4, 2001·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·S N WuH T Chiang
Aug 19, 2015·Biochimica Et Biophysica Acta·Ling YuDouglas C Eaton
Dec 17, 2005·Pharmacology & Therapeutics·Srinivas GhattaStephen T O'Rourke
Jan 16, 2002·Current Biology : CB·Nina M StoreyDavid L Armstrong
Nov 7, 2014·Frontiers in Behavioral Neuroscience·Joel S CavalloJoseph Farley
May 11, 2001·Neuropeptides·Z Csaba, P Dournaud
Dec 15, 2016·Frontiers in Physiology·Silvia S Antollini, Francisco J Barrantes
Jan 19, 2005·World Journal of Gastroenterology : WJG·Hai-Feng ZhengWen-Xie Xu
May 2, 1998·Journal of Neurophysiology·P SchweitzerG R Siggins
Feb 22, 2017·Frontiers in Physiology·Fredrik Elinder, Sara I Liin
Sep 24, 1998·The American Journal of Physiology·R S Barlow, R E White
May 12, 1998·The American Journal of Physiology·J D StockandS C Sansom
May 23, 1997·The Journal of Biological Chemistry·R W HipkinA Schonbrunn
Aug 3, 2000·American Journal of Physiology. Heart and Circulatory Physiology·R S BarlowR E White
Sep 26, 2000·American Journal of Physiology. Cell Physiology·D D DensonD C Eaton
Nov 24, 1999·The American Journal of Physiology·G I SandleR B Lomax
Jan 14, 1999·The American Journal of Physiology·D D DensonD C Eaton
Sep 26, 2003·Biochimica Et Biophysica Acta·Lars Neisig MøllerJens Juul Holst

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.