Somatotropic axis and body weight in pre-menopausal and post-menopausal women: evidence for a neuroendocrine derangement, in absence of changes of insulin-like growth factor binding protein concentrations

Human Reproduction
F BernardiA R Genazzani

Abstract

The altered function of the somatotropic axis observed in perimenopause may underlie the changes in body weight and fat distribution. The aim of the present study was to evaluate, in pre-menopausal and post-menopausal women with body mass index (BMI) > or = or <25, the basal plasma levels of growth hormone (GH), insulin-like growth factor (IGF)-I and -II, IGF binding protein (IGFBP)-1 and -3, and the response of GH and IGFBP-1 and -3 to GH releasing hormone (GHRH) and GHRH plus arginine tests. GH and IGF-I basal concentrations were significantly higher in pre-menopausal than in post-menopausal women, while IGF-II, IGFBP-1 and IGFBP-3 concentrations did not vary significantly. IGFBP-1, but not IGFBP-3, concentrations were higher in lean than in obese patients. Insulin concentrations were significantly higher in obese patients, while no differences were observed between pre-menopausal and post-menopausal women. In all subjects, GH concentrations increased significantly during GHRH test; pre-menopausal and lean women showed a higher response compared to post-menopausal and obese women. The GHRH plus arginine test stimulated GH response in all women, irrespective of age and BMI. IGFBP-1 and -3 concentrations did not vary in respons...Continue Reading

Citations

Feb 15, 2001·Fertility and Sterility·H J CardimJ A Pinotti
Jan 5, 2000·Journal of Internal Medicine·H W PetersJ C Witteman
Feb 11, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·C SieversH J Grabe
Oct 31, 2002·Human Psychopharmacology·Kurt Heininger
Aug 3, 2000·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·A MilewiczU Tworowska
Apr 20, 2001·The Proceedings of the Nutrition Society·R Kaaks, A Lukanova

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