PMID: 1204654Dec 15, 1975Paper

Some actions of purified toxins from Bungarus fasciatus venom on isolated pig-heart mitochondria

European Journal of Biochemistry
P Leblanc, M Lievremont

Abstract

I. In the presence of succinate as an oxidation substrate, neurotoxins alpha, beta and gamma induce the following. Firstly, an increasing stimulation of oxygen uptake, which in potentiated by 25 muM Ca2+, Mg2+ 1.3 mM completely inhibits the effect of toxin alpha but not of toxins beta and gamma. Secondly, a depletion of the Mg2+, Ca2+ and K+ content of the water-soluble and membrane-bound mitochondrial compartments, following complex kinetics, which suggest a multistep interaction mechanism of the toxins with the mitochondria. 25 muM Ca2+ also potentiates the effect of the toxins on these ionic flows. Thirdly, no decrease of turbidity with toxin alpha, and a limited decrease with toxins beta and gamma. 2. In the absence of respiration, the neurotoxins induce a cationic depletion, the kinetics of which are different than with succinate, suggesting an instantaneous maximal effect on the inner membrane. Toxins beta and gamma (but not alpha) induce, under these conditions, a turbidity decrease of large amplitude, which is proportional to the amount of toxin added and tends to reach a maximum. With gamma toxin this turbidity decrease is faster than the rate of water uptake (which never exceeds 18%) indicating that it is due rather t...Continue Reading

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