Some aspects of astroglial functions and aluminum implications for neurodegeneration

Brain Research Reviews
David A Aremu, Shunsuke Meshitsuka

Abstract

The present decade had witnessed an unprecedented attention focused on glial cells as a result of their unusual physiological roles that are being unraveled. It is now known that, rather than being a mere supporter of neurons, astroglia are actively involved in their modulation. The aluminum hypothesis seems to have been laid to rest, probably due to contradictory epidemiological reports on it as a causative factor of neurodegenerative diseases. Surprisingly, newer scientific evidences continue to appear and recent findings have implicated astrocytes as the principal target of its toxic action. In view of the likely detrimental effects of the interaction between these two infamous partners in neuroscience on neurons and nervous system, we have reviewed some aspects of glia-neuron interaction and discussed the implications of aluminum-impaired astrocytic functions on neurodegeneration. Because sporadic causes still account for the majority of the neurodegenerative diseases of which Alzheimer's disease is the most prominent, it has been suggested that neurotoxicologists should not relent in screening for the environmental agents, such as aluminum, and that considerable attention should be given to glial cells in view of the likel...Continue Reading

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Citations

Mar 25, 2011·Environmental Health and Preventive Medicine·David A AremuShunsuke Meshitsuka
Nov 17, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Shunsuke Meshitsuka, David A Aremu
Oct 14, 2011·Ecotoxicology and Environmental Safety·María Lourdes Fernández-DávilaMarcela Galar-Martínez
Sep 9, 2009·Journal of Inorganic Biochemistry·Ojeiru F EzomoShunsuke Meshitsuka
Aug 7, 2007·Journal of Inorganic Biochemistry·Paula P Gonçalves, Virgília S Silva
Nov 12, 2016·International Journal of Environmental Research and Public Health·Mohammad H RahbarEric Boerwinkle
Mar 14, 2008·International Journal of Immunopathology and Pharmacology·Q L ZhangQ Niu
Dec 29, 2020·Journal of Chemical Neuroanatomy·Wafaa LaabbarHalima Gamrani

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