Some aspects of the detection of potential mutagenic agents in Drosophila.

Mutation Research
E Vogel

Abstract

The Drosophila system is a valuable test for detecting and characterizing mutagenic agents. Tester strains are available or can be synthesized for determining almost all types of genetical change ranging from gene mutations to chromosome rearrangements in a great variety of cell types of both sexes. Metabolic activation of all groups of indirect mutagens tested so far (aryldialkyltriazenes, cyclophosphamides, nitrosamines, azo-, hydrazo- and azoxyalkanes, aflatoxins, and polycyclic hydrocarbons; about 35 representatives in all), gives strong although indirect support for the considerable metabolizing ability of Drosophila. This capability would be expected from comprehensive biochemical data on bioactivation of foreign compounds in other insects. From a comparison of which types of genetical change are induced at high, low and threshold concentrations, it appears that lethal tests remain the most reliable method for any screening program. Mutagenic agents such as diethylnitrosamine, hycanthone and certain triazenes, which are highly efficient in the induction of recessive lethals (gene mutations and/or deficiencies), would not have been detected in Drosophila if chromosome breakage were the only indicator for mutagenic activity...Continue Reading

References

Jan 1, 1974·Mutation Research·A G Knaap, P G Kramers
Aug 1, 1974·Mutation Research·F H Sobels
Mar 15, 1972·International Journal of Cancer. Journal International Du Cancer·O G Fahmy, M J Fahmy
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Jan 1, 1971·Humangenetik·G Röhrborn, I Hansmann
Nov 1, 1969·Mutation Research·P K Datta, E Schleiermacher

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Citations

Aug 1, 1975·Mutation Research·F H Sobels
Nov 1, 1976·Mutation Research·F H Sobels, E Vogel
Oct 1, 1977·Mutation Research·W G Blijleven, E Vogel
Jul 1, 1977·Mutation Research·F G Verburgt, E Vogel
Nov 1, 1979·Mutation Research·T D NguyenM M Green
Dec 1, 1987·Mutation Research·F H Sobels
Jan 1, 1976·Mutation Research·G R Mohn, J Ellenberger
Aug 1, 1976·Mutation Research·B E Matter
Jun 1, 1981·Mutation Research·B J KilbeyE W Vogel
Jul 1, 1976·Mutation Research·I LaamanenT Meretoja
Sep 14, 2000·Mutation Research·E R Muñoz, B M Barnett
Jun 1, 1976·Environmental Health Perspectives·F H Sobels, E Vogel
Dec 1, 1980·Food and Cosmetics Toxicology

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