PMID: 2506355Sep 1, 1989Paper

Some aspects of the organization and evolution of the genetic code

Journal of Molecular Evolution
Massimo Di Giulio

Abstract

In this paper, I define a measure of the relative position of each amino acid in the genetic code by means of a 21-dimensional vector describing its potential for mutation, in a single step, to each of the other amino acids, or to a chain termination codon. This measure allows us to make a systematic investigation of the type and number of the physicochemical properties of the amino acids that were involved in evolution. The polar character and size of amino acids are identified in this analysis as properties that played a leading role in the evolutionary history of the genetic code. The application of cluster analysis and discriminant analysis reveals the characteristics of the structural organization of the genetic code. Finally, I suggest the existence of a relationship between the molecular weight of the amino acids and the number of synonymous codons.

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Citations

Sep 1, 1994·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·M Di Giulio
Dec 1, 1995·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·M Di Giulio
Dec 1, 1996·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·M Di Giulio
Jan 1, 1992·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·M Di Giulio
Nov 1, 1991·Journal of Molecular Evolution·D Haig, L D Hurst
Feb 10, 2012·Acta Biotheoretica·L Almeida, J Demongeot
Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A L BermanD I Frishman
Mar 1, 2002·Journal of Biological Physics·L FrappatP Sorba
Nov 5, 2013·Archaea : an International Microbiological Journal·Liudmila S YafremavaGustavo Caetano-Anollés
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·T A RonnebergS J Freeland
Nov 26, 2015·RNA Biology·Charles W Carter, Richard Wolfenden
Apr 8, 2010·Journal of Theoretical Biology·Fernando Castro-Chavez
Sep 9, 2009·Journal of Theoretical Biology·V R Chechetkin, V V Lobzin
Jan 24, 2007·Journal of Theoretical Biology·Hani GoodarziHamed Shateri Najafabadi
Oct 29, 2013·Journal of Molecular Evolution·Massimo Di Giulio
Mar 17, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J Tze-Fei Wong
Jun 28, 2005·Journal of Theoretical Biology·Massimo Di Giulio
Mar 16, 2000·Journal of Theoretical Biology·M Di Giulio
Oct 20, 2010·Journal of Theoretical Biology·V R Chechetkin, V V Lobzin
Jun 4, 2013·Journal of Theoretical Biology·Massimo Di Giulio
Apr 25, 2000·Journal of Theoretical Biology·A R CavalcantiR Ferreira
Aug 10, 2000·Journal of Theoretical Biology·M Di Giulio
Oct 27, 2018·Journal of Molecular Evolution·Massimo Di Giulio
Jan 1, 1994·Plant Molecular Biology·A Quesada, E Fernández
Jan 1, 1993·Molecular & General Genetics : MGG·E DuncansonJ L Wray
Mar 12, 2004·Annual Review of Plant Physiology and Plant Molecular Biology·Wilbur H. Campbell
Dec 14, 2018·BMC Evolutionary Biology·Małgorzata WnętrzakPaweł Mackiewicz
Dec 27, 1993·Physical Review Letters·J E Hornos, Y M Hornos
Aug 11, 2021·Molecular Biology and Evolution·Hana Rozhoňová, Joshua L Payne

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