Some assembly required: dedicated chaperones in eukaryotic proteasome biogenesis.

Biological Chemistry
Andrew R Kusmierczyk, Mark Hochstrasser

Abstract

The 26S proteasome is the key eukaryotic protease responsible for the degradation of intracellular proteins. Protein degradation by the 26S proteasome plays important roles in numerous cellular processes, including the cell cycle, differentiation, apoptosis, and the removal of damaged or misfolded proteins. How this 2.5-MDa complex, composed of at least 32 different polypeptides, is assembled in the first place is not well understood. However, it has become evident that this complicated task is facilitated by a framework of protein factors that chaperone the nascent proteasome through its various stages of assembly. We review here the known proteasome-specific assembly factors, most only recently discovered, and describe their potential roles in proteasome assembly, with an emphasis on the many remaining unanswered questions about this intricate process of assisted self-assembly.

References

Nov 1, 1994·Nature Structural Biology·P ZwicklW Baumeister
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A AmsterdamW Baumeister
Jan 1, 1995·Annual Review of Genetics·J J Monaco, D Nandi
Sep 23, 1996·Mutation Research·R J Brennan, R H Schiestl
Jan 1, 1996·Annual Review of Genetics·M Hochstrasser
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·C S Arendt, M Hochstrasser
Oct 6, 1997·The Journal of Biological Chemistry·W HeinemeyerD H Wolf
Oct 8, 1997·The EMBO Journal·E A ReitsJ Trowsdale
Feb 6, 1998·Journal of Molecular Biology·W L GerardsW Boelens
May 9, 1998·Journal of Structural Biology·J WalzW Baumeister
Jun 20, 1998·Molecular and Cellular Biology·M H GlickmanD Finley
Nov 21, 1998·The EMBO Journal·C R WilkinsonC Gordon
Jul 27, 1999·The Journal of Biological Chemistry·S J RussellS A Johnston
Jun 30, 2000·Biochemical and Biophysical Research Communications·Y SaekiH Yokosawa
Jul 13, 2000·Molecular Cell Biology Research Communications : MCBRC·T A GriffinR A Colbert
Sep 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·L BurriF Lévy
Nov 4, 2000·Nature Structural Biology·M GrollD Finley
Dec 5, 2000·Molecular Biology of the Cell·A P GaschP O Brown
Feb 24, 2001·Cellular and Molecular Life Sciences : CMLS·T Dokland
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y Xie, A Varshavsky
Mar 1, 2002·Advances in Protein Chemistry·P ZwicklW Baumeister
Apr 2, 2002·Journal of Molecular Biology·Andrea LehmannCordula Enenkel
May 17, 2002·Structure·Masaki UnnoTomitake Tsukihara
Jul 3, 2002·The EMBO Journal·Vicença UstrellMartin Rechsteiner
Jul 31, 2002·The Journal of Biological Chemistry·Rumana BaharMasatoshi Tagawa
Nov 1, 2002·Molecular Cell·David S LeggettDaniel Finley
Apr 25, 2003·Journal of Cell Science·Elizabeth A PalmerArdythe A McCracken
Oct 17, 2003·Nature·Won-Ki HuhErin K O'Shea
Jan 15, 2004·The Journal of Biological Chemistry·Paula C RamosR Jürgen Dohmen

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Citations

May 5, 2009·Nature·Jeroen RoelofsDaniel Finley
Apr 19, 2011·Nature Structural & Molecular Biology·Andrew R KusmierczykMark Hochstrasser
Feb 4, 2011·Molecular Biology of the Cell·Anca F SavulescuAmnon Harel
Jun 6, 2009·Annual Review of Biochemistry·Daniel Finley
Oct 3, 2012·Genetics·Daniel FinleyPeter Kaiser
Jan 16, 2009·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Keiji Tanaka
Mar 19, 2013·Annual Review of Biochemistry·Robert J Tomko, Mark Hochstrasser
Mar 20, 2013·Biochimica Et Biophysica Acta·Mary J Kunjappu, Mark Hochstrasser
Apr 30, 2010·Trends in Cell Biology·Lynn BedfordJeroen Roelofs
Jul 14, 2010·Molecular Cell·Andrea LehmannCordula Enenkel
Aug 2, 2018·Nature Reviews. Molecular Cell Biology·Adrien Rousseau, Anne Bertolotti
Oct 22, 2014·Molecular and Cellular Biology·Hideki YashirodaShigeo Murata
Jan 24, 2009·Nature Reviews. Molecular Cell Biology·Shigeo MurataKeiji Tanaka
Jun 2, 2011·The Journal of Biological Chemistry·Young-Chan Kim, George N DeMartino
Jan 16, 2010·Biochemical Society Transactions·Ana C MatiasR Jürgen Dohmen
Mar 7, 2009·Chemical Reviews·António J MarquesR Jürgen Dohmen
Jun 30, 2009·Methods : a Companion to Methods in Enzymology·Anne E Bunner, James R Williamson

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