PMID: 36316Mar 1, 1979

Some biochemical characteristics of hormone-secreting pituitary tumors and of the host's anterior pituitary gland

Molecular and Cellular Endocrinology
I Nagy, R M MacLeod

Abstract

The activity of some glycolytic, oxidative, and degradative enzymes was studied in transplanted rat hormone-secreting pituitary tumors MtTW15 and 7315a and in the host pituitary gland. The elevated serum-hormone concentrations produced by 7315a tumor decreased the size of the host's pituitary gland, its hormone content, and G6P-DH, LDH, PK, and ICDH, but produced no changes in MDH, acid phosphatase, cathepsin-D, and LYSAR enzyme activities (mU/mg tissue). LDH and PK activities were greater in unit weight of pituitary tumors than in pituitary glands. Although more G6P-DH was found in MtTW15 tumor than in normal pituitary tissue, less of the enzyme was detected in 7315a pituitary tumor. It is concluded that elevated serum pituitary hormones selectively decrease hormone production and the activity of some enzymes in the pituitary gland, presumably through a feedback mechanism.

References

May 1, 1974·Acta Endocrinologica·H KuhlH D Taubert
Sep 1, 1974·Acta Endocrinologica·E C Griffiths, K C Hooper
Nov 1, 1974·Journal of Neurochemistry·V N LuineB S McEwen
Dec 1, 1973·Acta Endocrinologica·M A Pisarev, N Altschuler
Dec 1, 1966·Revue de neuropsychiatrie infantile et d'hygiène mentale de l'enfance·C L ChenJ Meites
Mar 1, 1967·Endocrinology·C Hoch-LigetiH H Grantham
May 1, 1956·Archives of Biochemistry and Biophysics·R K MEYER, K H CLIFTON
Dec 1, 1960·Endocrinology·J B FIELDP JOHNSON

Related Concepts

Glycolysis
NADH
NADP
Neoplasms, Experimental
Peptide Hydrolases
Pituitary Gland, Anterior
Pituitary Carcinoma
Prolactin

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