PMID: 9553838Apr 29, 1998Paper

Some biological actions of alkylglycerols from shark liver oil

The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy
P T PuglieseJ Brohult

Abstract

Shark liver oil has been used for over 40 years as both a therapeutic and preventive agent. The active ingredients in shark liver oil have been found to be a group of ether-linked glycerols known as alkylglycerols. Initial clinical use was for treating leukemias, and later to prevent radiation sickness from cancer x-ray therapy. Studies over the last 30 years have shown that alkylglycerols are multifunctional. The level of natural alkylglycerols rises within tumor cells, apparently in an effort to control cell growth. Recent studies indicate that the activation of protein kinase C, an essential step in cell proliferation, can be inhibited by alkylglycerols. This action suggests a competitive inhibition of 1.2-diacylglycerol by alkylglycerols. Further studies on the immunostimulatory action of alkylglycerols suggest a primary action on the macrophage. The process of macrophage activation has been demonstrated with both synthetic and natural alkylglycerols. While the exact mechanism has not been found, both an autocrine and paracrine system have been suggested. Shark liver is a major natural source of alkylglycerols, which have no known side effects in dosages of 100 mg three times a day. The information presented in this article...Continue Reading

References

Jan 1, 1977·Acta Obstetricia Et Gynecologica Scandinavica·A BrohultI Joelsson
Jun 11, 1975·The Journal of Experimental Medicine·C BiancoS C Silverstein
Jan 1, 1987·Cancer Immunology, Immunotherapy : CII·N YamamotoR A Pieringer
May 1, 1986·Annales De L'Institut Pasteur. Immunology·C F Nathan
Mar 15, 1988·Experientia·D Migliore-Samour, P Jollès
Nov 1, 1987·Lipids·H BrachwitzI Fichtner
Jan 1, 1986·Pathology and Immunopathology Research·L M McManus
Jan 1, 1986·Acta Obstetricia Et Gynecologica Scandinavica·A BrohultI Joelsson
Mar 29, 1985·Biochimica Et Biophysica Acta·B Z Ngwenya, N Yamamoto
Jan 1, 1984·Annual Review of Immunology·D O Adams, T A Hamilton
Feb 1, 1983·Experimental and Molecular Pathology·J C LewisM G Bond
Feb 9, 1995·Biochimica Et Biophysica Acta·M RobinsonT R Warne
Dec 31, 1956·Acta Physiologica Scandinavica·S BERGSTROM, R BLOMSTRAND
May 1, 1958·Clinica Chimica Acta; International Journal of Clinical Chemistry·J BODMAN, J H HAISIN
Apr 1, 1959·Proceedings of the Society for Experimental Biology and Medicine·R BLOMSTRAND, E H AHRENS

❮ Previous
Next ❯

Citations

Dec 25, 2009·European Journal of Applied Physiology·Daniele Cristina VitorinoLuiz Claudio Fernandes
Nov 23, 2006·Food Additives and Contaminants·Kazuhiko AkutsuKazuichi Hayakawa
Jun 19, 2013·Journal of Medicinal Food·Leniher CastanDaliana Lobo
Nov 11, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Anna AielloWerner E G Müller
Jun 18, 2011·Lipids in Health and Disease·Ann B MoserJoseph G Hacia
Sep 30, 2010·Journal of Oleo Science·L S Afinisha Deepam, C Arumughan
Jun 10, 2009·Journal of Ethnopharmacology·Monire HajimoradiNafiseh Pakravan
Aug 4, 2009·Pharmacoepidemiology and Drug Safety·Ingela JacobssonStaffan Hägg
Jun 3, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·F PédronoA B Legrand
Jan 24, 2002·Biology of Reproduction·Céline CheminadeAlain B Legrand
Nov 6, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Nastaran SamimiMojtaba Farjam
Dec 22, 2009·Journal of Agricultural and Food Chemistry·Arturo AnadónCarlos Torres

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved