PMID: 1191694Dec 1, 1975Paper

Some characteristics of monocarboxylic acid transfer across the cell membrane of epithelial cells from rat small intestine.

Biochimica Et Biophysica Acta
J M Lamers

Abstract

1. The translocation of monovalent organic anions (pyruvate, propionate, acetate and butyrate) across the cell membrane of isolated epithelial cells from rat small intestine was studied by measuring competitive inhibition kinetics, exchange diffusion and temperature dependence of the efflux rate. A possible function of a monocarboxylate carrier in intestine will be discussed. 2. Earlier studies on the inhibition of pyruvate transport of fatty acids were extended to propionate and found to show the same characteristics. The kinetics, however, appeared to be more complex by the contribution of several diffusion pathways for propionate. 3. The mechanism of countertransport was most compatible with an "accelerated exchange diffusion" and could be studied at both sides of the membrane. This exchange diffusion exhibited saturation kinetics. It is proposed that different monocarboxylate anions may have different affinities for a common carrier. 4. Temperature dependence of the efflux of pyruvate and propionate was studied. Arrhenius plots obtained were not found to be linear between 0 and 5 degrees C. Between 5 and 15 degrees C activation energies for pyruvate and propionate efflux rates were found to be 19.6 and 12.6 kcal/mol, respe...Continue Reading

References

Jun 11, 1975·Biochimica Et Biophysica Acta·J M Lamers, W C Hülsmann
Oct 10, 1974·Biochimica Et Biophysica Acta·A P HalestrapR M Denton

❮ Previous
Next ❯

Citations

Feb 14, 1979·Pflügers Archiv : European journal of physiology·Y UmesakiM Mutai
Dec 1, 1980·Pflügers Archiv : European journal of physiology·Y UmesakiM Mutai
Jan 1, 1984·The Journal of Membrane Biology·A Walter, J Gutknecht
Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·M Vernay
Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M Bugaut
Jan 1, 1977·Journal of Neurochemistry·W M Pardridge, W H Oldendorf
Oct 5, 2010·Physiology & Behavior·T L HanstockE H Clayton
Feb 2, 1978·Biochimica Et Biophysica Acta·B DeutickeE Beyer
Jan 5, 2002·Biochemical Pharmacology·Kenji KuwayamaNaoki Kamo
Feb 1, 1977·Archives of Biochemistry and Biophysics·S J StohsS Orrenius
Feb 23, 1978·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J L BrowneD H Smyth
Sep 1, 1981·Gut·J H Cummings
Nov 15, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Izumi KajiYasutada Akiba
Oct 4, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·W A AlrefaiP K Dudeja

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.