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Some characteristics of two azoreductase systems in rat liver. Relevance to the activity of 2-[4'-di(2"-bromopropyl)-aminophenylazo]benzoic acid (CB10-252), a compound possessing latent cytotoxic activity

Chemico-biological Interactions

Nov 1, 1975

H Autrup, G P Warwick

PMID: 149

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Abstract

The system involved in the reduction of 2-[4'-di(2''-bromopropyl) aminophenylazolbenzoic acid (CB10-252), an agent designed for treating primary liver cell cancer, has been demonstrated to be localised mainly in the 108 000 X g supernatant fraction of rat liver homogenate. It is also pr...read more

Mentioned in this Paper

Enzyme Inhibitors [MoA]
Azo Compounds
Liver Neoplasms
Entire Spleen
Supernatant
Enzyme Induction
Organ
NADP
Tissue Specificity
Cytoplasmic Matrix
Paper Details
References
    • References5
    • Citations15
    • References5
    • Citations15
  • Some characteristics of two azoreductase systems in rat liver. Relevance to the activity of 2-[4'-di(2"-bromopropyl)-aminophenylazo]benzoic acid (CB10-252), a compound possessing latent cytotoxic activity

    Chemico-biological Interactions

    Nov 1, 1975

    H Autrup, G P Warwick

    PMID: 149

    DOI:

    Abstract

    The system involved in the reduction of 2-[4'-di(2''-bromopropyl) aminophenylazolbenzoic acid (CB10-252), an agent designed for treating primary liver cell cancer, has been demonstrated to be localised mainly in the 108 000 X g supernatant fraction of rat liver homogenate. It is also pr...read more

    Mentioned in this Paper

    Enzyme Inhibitors [MoA]
    Azo Compounds
    Liver Neoplasms
    Entire Spleen
    Supernatant

    Related Papers

    Paper Details
    References
    • References5
    • Citations15
    • References5
    • Citations15
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