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Some characteristics of two azoreductase systems in rat liver. Relevance to the activity of 2-[4'-di(2"-bromopropyl)-aminophenylazo]benzoic acid (CB10-252), a compound possessing latent cytotoxic activity

Chemico-biological Interactions

Nov 1, 1975

H Autrup, G P Warwick

PMID: 149

Abstract

The system involved in the reduction of 2-[4'-di(2''-bromopropyl) aminophenylazolbenzoic acid (CB10-252), an agent designed for treating primary liver cell cancer, has been demonstrated to be localised mainly in the 108 000 X g supernatant fraction of rat liver homogenate. It is also pr...read more

Mentioned in this Paper

DLD gene
Hydrogen-Ion Concentration
Carboxyhemoglobin Measurement
Cyanide Measurement
Fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether
Supernatant
Dihydrolipoamide Dehydrogenase
Liver
Liver Neoplasms
Vitamin K 3
23
1
Paper Details
References
  • References5
  • Citations15
12

Some characteristics of two azoreductase systems in rat liver. Relevance to the activity of 2-[4'-di(2"-bromopropyl)-aminophenylazo]benzoic acid (CB10-252), a compound possessing latent cytotoxic activity

Chemico-biological Interactions

Nov 1, 1975

H Autrup, G P Warwick

PMID: 149

DOI:

Abstract

The system involved in the reduction of 2-[4'-di(2''-bromopropyl) aminophenylazolbenzoic acid (CB10-252), an agent designed for treating primary liver cell cancer, has been demonstrated to be localised mainly in the 108 000 X g supernatant fraction of rat liver homogenate. It is also pr...read more

Mentioned in this Paper

DLD gene
Hydrogen-Ion Concentration
Carboxyhemoglobin Measurement
Cyanide Measurement
Fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether
Supernatant
Dihydrolipoamide Dehydrogenase
Liver
Liver Neoplasms
Vitamin K 3
23
1

Related Papers

Paper Details
References
  • References5
  • Citations15
12
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