PMID: 7008891Nov 1, 1980Paper

Some clinical and metabolic aspects of propranolol in chronic schizophrenia

The British Journal of Psychiatry : the Journal of Mental Science
D J KingC D Kinney

Abstract

No benefit attributable to propranolol (1000 mg/day) could be detected in a trial lasting at least 22 weeks, 6 weeks of which was double-blind placebo-controlled, in 5 chronic schizophrenic patients. The mean propranolol CSF/plasma ration was 0.08, and there was good agreement between CSF and free plasma propranolol levels. Basal plasma prolactin was slightly but insignificantly reduced by propranolol, and metoclopramide-stimulated prolactin release was unaffected. Propranolol was associated with a significant temporary increase in HVA, a non-significant rise in 5-HIAA and a significant decrease in MHPG, in the lumbar cerebrospinal fluid of 4 patients.

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Citations

Aug 1, 1993·Biological Psychiatry·A L MillerJ Castiglioni
Jan 1, 1981·Pharmacology & Therapeutics·D N MiddlemissD T Greenwood
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·B B Sethi, S Dubé
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Mar 1, 1987·Mayo Clinic Proceedings·S C Jenkins, T Maruta
Mar 1, 1983·British Journal of Clinical Pharmacology·D J KingJ Liddle
Sep 1, 1981·Journal of Clinical and Hospital Pharmacy·M Peet, R A Yates
Jan 1, 1997·Journal of Psychopharmacology·F W DeakinJ S Hellewell
Nov 1, 2001·The Cochrane Database of Systematic Reviews·M CheineK Wahlbeck
Jun 1, 1986·The British Journal of Psychiatry : the Journal of Mental Science·R Manchanda, S R Hirsch
Aug 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·M PeetR A Yates
Aug 1, 1983·The British Journal of Psychiatry : the Journal of Mental Science·C R PughR G Priest
Dec 1, 1985·The British Journal of Psychiatry : the Journal of Mental Science·D EcclestonD A Stephens

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