PMID: 6987858Apr 1, 1980Paper

Some clinical considerations regarding the relation of coronary vasospasm to coronary atherosclerosis: a hypothetical pathogenesis

The American Journal of Cardiology
M MarzilliA Maseri

Abstract

This study explores the relation between coronary arterial spasm and the development of coronary atherosclerosis. The clinical history and coronary angiographic and electrocardiographic data in 212 consecutive patients with ischemic heart disease were correlated. These patients were classified into four groups: Group 1, patients without angiographic evidence of atherosclerosis; Group 2, patients with single vessel disease; Group 3, patients with double vessel disease; and Group 4, patients with significant narrowing of major coronary arteries. Although spontaneous angina occurred in all four groups, it was more common (55 percent) in the patients in Group 1, who were predominantly female and young. Spontaneous angina was confirmed in Group 1 with several techniques, including thallium-201 scintigraphy, ergonovine administration and electrocardiography during attacks of pain. Prior myocardial infarction was present with similar frequency in all four groups. A patient is discussed whose spontaneously occurring coronary arterial spasm later progressed to fixed arteriosclerotic narrowing requiring coronary bypass surgery. These observations and a review of the literature lend support to the hypothesis that coronary arterial spasm c...Continue Reading

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Citations

Jan 1, 1996·Heart and Vessels·H KültürsayA Akilli
Apr 1, 1980·The American Journal of Cardiology·B Lown, R A DeSilva
Oct 1, 1991·Journal of the American College of Cardiology·M NobuyoshiK Kimura
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Feb 28, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Ming-Jui HungWen-Jin Cherng
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Apr 20, 1999·Human Pathology·W H Gutstein
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Mar 1, 1990·International Journal of Cardiology·D CorradoP Maiolino
Jan 1, 1993·American Heart Journal·M TakenagaT Eto
Dec 8, 2000·Japanese Circulation Journal·M H JeongJ C Kang
Feb 11, 2012·Journal of the American College of Cardiology·Mario Marzilli, Alda Huqi
Sep 8, 2012·Journal of the American College of Cardiology·Mario MarzilliWilliam S Weintraub
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Oct 1, 1984·American Heart Journal·Y MatsudaR Kusukawa
Jun 15, 1990·The American Journal of Cardiology·S KushwahaM H Yacoub
Dec 1, 1984·Chest·T O Cheng

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