PMID: 9178184May 1, 1997Paper

Some effects of Cassia italica on the central nervous system in mice

The Journal of Pharmacy and Pharmacology
B H AliM O Tanira

Abstract

This work examines some effects of the crude ethanolic extract of the medicinal plant Cassia italica, given at single oral doses of 0.25, 0.5 or 1 g kg-1, on the central nervous system in mice. Several models of nociception have been used to examine the analgesic effect of the extract. HPLC fingerprinting of the extract was performed to ensure uniformity of the extract material used. In treated mice, the extract caused dose-related inhibition of acetic acid-induced abdominal constriction, and in the formalin test of antinociception the extract reduced formalin-induced pain in the second (late) but not in the first (early) phase of the pain. Treatment with the extract at doses of 0.5 and 1 g kg-1 significantly increased the reaction time in the hot-plate and warm-water tail-flick tests. Naloxone was ineffective in antagonizing the analgesic effect of C. italica on tail-flick and abdominal constriction tests, possibly indicating that the effect occurs via non-opiate pathways. The C. italica extract caused slight dose-related impairment of motor control which was significant only at a dose of 1 g kg-1. Treatment at the three doses used did not affect the rectal temperature of normothermic mice, but was effective in significantly r...Continue Reading

References

Apr 1, 1990·Journal of Ethnopharmacology·S Palanichamy, S Nagarajan
Jul 1, 1990·Clinical and Experimental Pharmacology & Physiology·D D Jamieson, P H Duffield
Sep 1, 1988·Journal of Pharmacological Methods·C W MurrayA Cowan
Jun 1, 1985·Journal of Neuroscience Methods·S HunskaarK Hole
Apr 1, 1995·Clinical and Experimental Pharmacology & Physiology·B H AliM O Tanira
Sep 1, 1994·The Journal of Pharmacy and Pharmacology·A R SantosJ B Calixto

❮ Previous
Next ❯

Citations

May 22, 2002·Journal of Ethnopharmacology·M H Al-YousufG Blunden
Jan 1, 2009·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·P MasokoL J Mampuru
Jul 2, 2005·Expert Opinion on Emerging Drugs·J B CalixtoA R Santos
Oct 31, 2002·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M H Al-YousufG Blunden
Jan 18, 2011·Experimental Biology and Medicine·Badreldin H AliAbderrahim Nemmar
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hui-Ting ChangCheng-Kuen Ho

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical and Experimental Pharmacology & Physiology
B H AliM O Tanira
Clinical and Experimental Pharmacology & Physiology
D D Jamieson, P H Duffield
© 2021 Meta ULC. All rights reserved