PMID: 6703041Mar 1, 1984Paper

Some effects of lead at mammalian neuromuscular junction

The American Journal of Physiology
J B Pickett, J C Bornstein

Abstract

The effect of lead on transmitter release was investigated in a rat phrenic nerve-hemidiaphragm preparation using conventional microelectrode techniques. Lead reduced the number of quanta released by a nerve stimulus (m) in a dose-dependent fashion. As extracellular Ca2+ concentration ([Ca2+]o) was varied in the absence of lead, a linear relationship between ln(m) and ln([Ca2+]o) was obtained. Lead shifted the relationship between ln(m) and ln([Ca2+]o) to the right without altering the slope. This suggested lead competed with Ca2+, which was confirmed by using a modified Lineweaver-Burk plot. Lead inhibits Ca2+ entry into frog sympathetic preganglionic nerve terminals, and a similar mechanism may underlie this present finding; such a mechanism, however, could not explain all the observed actions of lead. Lead increased the frequency of spontaneous quantal release in a dose-dependent manner, and 10(-4) M lead doubled the magnitude of facilitation of evoked release seen with five stimuli at 60 Hz. It is suggested that these effects result from inhibition of some, or all, of the nerve terminal's Ca2+ sequestration mechanisms.

References

Jun 1, 1975·The Journal of Physiology·E Alnaes, R Rahamimoff
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Citations

Dec 1, 1987·Pflügers Archiv : European journal of physiology·M Nishimura
Apr 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A H al DhaheriM A Fahim
Jul 25, 1985·The New England Journal of Medicine·P E Cryer, J E Gerich
Dec 1, 1989·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·G AudesirkJ Przekwas
Sep 1, 1994·Environmental Health Perspectives·H P VijverbergR G van Kleef
Jan 1, 1985·Progress in Neurobiology·G Audesirk

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