PMID: 6401429Jan 1, 1983Paper

Some effects of maternal pethidine administration on the newborn

British Journal of Obstetrics and Gynaecology
G RoothA Huch

Abstract

The effects of maternal pethidine administration (100 mg intramuscularly) were investigated in 150 infants at 1-2 h after birth, 95 infants whose mothers had not received pethidine served as a control group. Pethidine administration showed no effect on pH or PCO2 of cord blood and neonatal arterial blood at 1-2 h after birth if the time interval between pethidine administration and delivery was less than or equal to 1 h. However, when the interval was greater than 1 h: umbilical vein blood PCO2 was higher; neonatal arterial blood PCO2 was higher; neonatal baseline heart rate was higher, although long-term variability was similar; the percentage time spent crying was considerably reduced compared with the corresponding values in the control group. The long-term effects of pethidine are unknown but the adverse neonatal factors particularly if the time interval between administration of the drug and delivery is greater than 1 h should be kept in mind.

References

Jun 1, 1975·Archives of General Psychiatry·R N EmdeB Suzuki
Feb 1, 1974·American Journal of Obstetrics and Gynecology·Y BrackbillD Abramson
Jan 1, 1968·Acta Obstetricia Et Gynecologica Scandinavica·G Koch, H Wendel
Aug 1, 1982·British Journal of Obstetrics and Gynaecology·M S RahmanA Lysikiewicz
Jul 1, 1980·European Journal of Clinical Pharmacology·P L Morselli, V Rovei
Feb 1, 1955·American Journal of Obstetrics and Gynecology·E S TAYLORL C WALKER
Aug 15, 1964·American Journal of Obstetrics and Gynecology·S M SHNIDER, F MOYA

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Citations

May 16, 2002·American Journal of Obstetrics and Gynecology·Leanne Bricker, Tina Lavender
Jun 7, 2006·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Gerald G Briggs, Stephanie R Wan
Dec 1, 1996·Pharmacology, Biochemistry, and Behavior·M S Golub

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