Some effects of nicotine on food and water intake in undeprived rats

British Journal of Pharmacology
P B Clarke, R Kumar

Abstract

Undeprived rats were tested in their home cages for intake of water and powered food, starting 15 min after subcutaneous (s.c.) injection of (-)-nicotine bitartrate or 0.9% w/v NaCl solution (saline). In the first 2 h, nicotine (0-0.4 mg kg-1 base) markedly reduced water intake in a dose-related way, leaving food intake unchanged. Food and water intake up to 24 h after injection was unaffected. Rats (n = 6 per group) were then injected daily with nicotine (0.4 mg kg-1 base, s.c.) or saline for one month. Intermittent tests with saline (in place of nicotine) during this period did not reveal any signs of abstinence. A dose-response study similar to the first was then carried out, and little or no tolerance was found to the hypodipsic action of nicotine. Nicotine also reduced food intake, irrespective of chronic treatment. Subsequently, daily injections were discontinued, and spontaneous intake did not differ in rats previously maintained on nicotine, relative to control animals. Mecamylamine (0.3, 1.5 mg kg-1, s.c.) prevented nicotine-induced hypodipsia, whereas chlorisondamine (0.02, 0.1 mg kg-1 s.c.) was ineffective. Both ganglion blockers reduced food intake. Nicotine did not reduce drinking in rats preloaded with a hypertoni...Continue Reading

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Citations

Jan 1, 1987·Psychopharmacology·P B Clarke, H C Fibiger
Oct 1, 1988·European Journal of Drug Metabolism and Pharmacokinetics·B F ThomasM D Aceto
Jun 1, 1986·Pharmacology, Biochemistry, and Behavior·A C CollinsM J Marks
Sep 18, 2002·Brain Research. Developmental Brain Research·Craig J Slawecki, Cindy L Ehlers
Feb 1, 1992·British Journal of Addiction·K A Perkins
Dec 6, 2011·The Journal of Endocrinology·Michael MangubatTheodore C Friedman
Jun 9, 2009·Neuropharmacology·Matthew M FordDeborah A Finn
Oct 6, 2015·Pharmacology, Biochemistry, and Behavior·Tanseli NesilSakire Pogun
Jan 12, 2000·Brain Research·R IsolaM Hadjiconstantinou
May 1, 1988·Journal of Neurochemistry·S S Katyare, J M Shallom
Jan 23, 2018·Psychopharmacology·Laura E RupprechtAlan F Sved
Aug 12, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ee Tsin WongManuel C Peitsch

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