Some effects of pimozide and of shifts in sucrose concentration on lick rate, duration, and interlick interval

Pharmacology, Biochemistry, and Behavior
S E Gramling, S C Fowler

Abstract

Multiple dependent measures were employed to characterize the licking behavior of rats exposed to shifts in reward magnitude or injected with pimozide (PIM). Nondeprived rats licked either a 32% (n = 14) or 4% (n = 15) sucrose solution in daily 10 min sessions. Rats in the 32% condition were then down-shifted to either a 16% (n = 7) 4% (n = 7) sucrose solution. Rats in the 4% condition were up-shifted to either 16% (n = 7) or 32% (n = 8) sucrose solution. The response profiles generated by those rats shifted to a lower reward magnitude were contrasted with either rats shifted from a 32% sucrose solution to a no-reward (plain tap water) condition, or with rats maintained on a 32% sucrose solution and administered the neuroleptic PIM (0.5 mg/kg or 1.0 mg/kg). Rats down-shifted from a 32% to 4% sucrose solution generated response profiles more similar to rats shifted to plain tap water than rats maintained on a 32% sucrose solution and administered PIM. These results suggested that PIM treatment is not functionally equivalent to either a shift to no-reward or to a shift to reduced reward conditions.

References

Feb 1, 1975·Journal of Comparative and Physiological Psychology·C F Flaherty, J Largen
Apr 1, 1985·Pharmacology, Biochemistry, and Behavior·S E Gramling, S C Fowler
May 1, 1985·Pharmacology, Biochemistry, and Behavior·N Geary, G P Smith
Sep 1, 1969·Journal of Comparative and Physiological Psychology·J D Corbit, E S Luschei
Oct 1, 1984·Pharmacology, Biochemistry, and Behavior·S E GramlingK R Collins
Apr 1, 1983·Behavioral Neuroscience·S Hsiao, R Spencer
Sep 1, 1981·Pharmacology, Biochemistry, and Behavior·S Xenakis, A Sclafani
Jun 1, 1980·Pharmacology, Biochemistry, and Behavior·T Gray, R A Wise

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Citations

Feb 1, 1990·Pharmacology, Biochemistry, and Behavior·D L Wolgin
May 1, 1992·Pharmacology, Biochemistry, and Behavior·C F FlahertyP S Grigson
Jan 1, 1989·Annals of the New York Academy of Sciences·J D Davis
Dec 16, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C M MathesA C Spector
May 13, 2010·Pharmacology, Biochemistry, and Behavior·Maria Elena CanuPaolo S D'Aquila

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