PMID: 6162807Aug 1, 1980Paper

Some effects of products from necrotic regions of tumours on the in vitro migration of cancer and peritoneal exudate cells

International Journal of Cancer. Journal International Du Cancer
G A Turner, L Weiss

Abstract

The invasion of normal tissues by cancer cells and the infiltration of tumours by macrophages to some degree involves active translatory movements by these cells. As necrosis is a common occurrence in solid tumours, we have studied the interactions of saline extracts from the necrotic regions of rat Walker-256 tumours and mouse Gardner lymphosarcomas on the transmembrane, in vitro migration of Walker and Gardner cancer cells, and rat and mouse peritoneal macrophages. Necrotic extracts enhanced cell migration independently of chemotactic activity, an effect which was partially reduced by Trasylol, an inhibitor of neutral proteases. Rat liver lysosomal preparations which contain lower levels of neutral proteases than necrotic extract, inhibited or had no effects on cell migration, and the lysosomal stabilizer hydrocortisone did not inhibit the action of necrotic extracts. The results indicate that necrosis may enhance the migration of cancer cells out of tumours and the migration of macrophages into them. The extracts act partially through their neutral protease content. In contrast to the enhancement of cell detachment by necrotic extracts, which previous work has shown to be partially mediated by their indirect effect in causin...Continue Reading

References

Dec 1, 1976·Analytical Biochemistry·R Levenson
Jan 1, 1979·Monographs on Endocrinology·A S Fauci
Aug 15, 1978·International Journal of Cancer. Journal International Du Cancer·L Weiss
Jan 1, 1976·Journal of Immunological Methods·I E Addison, J W Babbage
Jul 15, 1977·International Journal of Cancer. Journal International Du Cancer·L Weiss
May 1, 1972·Analytical Biochemistry·A J Barrett
Feb 1, 1966·Clinica Chimica Acta; International Journal of Clinical Chemistry·A L Babson, G E Phillips
Nov 28, 1967·Biochimica Et Biophysica Acta·H RagabA L Tappel

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Citations

Jan 1, 1983·Cancer Metastasis Reviews·L Weiss, P M Ward
Jan 1, 1982·Journal of Cancer Research and Clinical Oncology·R RoubinP Burtin
Jan 1, 1988·Journal of Cancer Research and Clinical Oncology·A V D'AmicoR K Babayan
Apr 15, 1988·Biochemical and Biophysical Research Communications·J P FreyerA G Saponara

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