Jan 1, 1976

Some evidence for aldosterone action on 2,3-diphosphoglycerate level in human red cells

Metabolism: Clinical and Experimental
D BöningK A Meurer


In healthy male subjects aldosterone excretion and plasma renin activity were reduced by a 4-6 hr head-out immersion in thermoindifferent water baths (35.5 +/- 0.1 degrees C). The red cell 2,3-diphosphoglycerate (DPG) concentration before and throughout immersion period was positively correlated both with aldosterone excretion in 2 hr pooled urine (r = +0.69; 2 p less than 0.001) and with renin activity (r = + 0.54; 2p less than 0.001) despite a concomitant increase of cubital venous pH and inorganic phosphate concentration. These findings furnish evidence for a regulatory role of aldosterone in DPG metabolism, possibily by a direct influence on red cell glycolysis.

  • References5
  • Citations3


  • References5
  • Citations3


Mentioned in this Paper

Metabolic Process, Cellular
Aldosterone Measurement
Phosphate Measurement
Body Excretions
Diphosphoglyceric Acids
Metabolic Pathway
Excretory Function

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