PMID: 6110749Dec 1, 1980Paper

Some factors influencing the metabolism of benzylamine by type A and B monoamine oxidase in rat heart and liver

The Journal of Pharmacy and Pharmacology
D ParkinsonB A Callingham

Abstract

The ability of MAO-A and MAO-B to metabolize benzylamine in vitro has been investigated in mitochondrial preparations from rat liver and heart. Although under normal circumstances benzylamine appeared to be metabolized exclusively by MAO-B in the rat liver, a contribution by both MAO-A and a clorgyline-resistant enzyme component was revealed when the MAO-B activity was much reduced by pretreatment of the mitochondria with appropriate concentrations of deprenyl. These three enzyme activities also contributed to benzylamine deamination in rat heart mitochondria. However, binding studies with [3H]pargyline, which provided an estimate of the respective concentrations of MAO-A and MAO-B active centres in heart mitochondria, indicated a ratio between MAO-A and MAO-B, markedly different from that shown by plots of inhibition of benzylamine metabolism by various concentrations of clorgyline. The interpretation of these clorgyline plots is discussed in terms of the kinetic constants of both MAO-A and MAO-B, and the relative amounts of each enzyme. It is proposed that although the turnover rate constant for benzylamine metabolism by MAO-A is much smaller than that shown by MAO-B, in those tissues containing a large ratio of MAO-A:MAO-B c...Continue Reading

References

Oct 1, 1977·The Journal of Pharmacy and Pharmacology·C J Fowler, B A Callingham
Nov 1, 1979·The Journal of Pharmacy and Pharmacology·G A Lyles, B A Callingham
Aug 1, 1979·Biochemical Pharmacology·D J EdwardsM C Venetti
Jun 1, 1979·Pharmacological Research Communications·E J Dial, D E Clarke
Jan 1, 1978·Biochemical Pharmacology·T J Mantle, K F Tipton
Dec 1, 1973·The Journal of Pharmacy and Pharmacology·B A Callingham, R Laverty
Dec 1, 1974·The Journal of Pharmacy and Pharmacology·G A Lyles, B A Callingham
Jan 1, 1974·Reviews of Physiology, Biochemistry and Pharmacology·H Blaschko
Aug 1, 1973·British Journal of Pharmacology·J F CoquilN H Neff
Jul 1, 1968·Biochemical Pharmacology·J P Johnston
Jan 1, 1980·The Journal of Pharmacy and Pharmacology·D Parkinson, B A Callingham
Dec 1, 1980·The Journal of Pharmacy and Pharmacology·D ParkinsonB A Callingham
Jan 1, 1953·Scandinavian Journal of Clinical and Laboratory Investigation·J GOA

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Citations

Oct 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·M Eriksson, C J Fowler
Mar 15, 1983·Experientia·C Mitra, S R Guha
Dec 1, 1983·Veterinary Research Communications·B A Callingham
Apr 1, 1991·Journal of Neuroendocrinology·M SchumacherJ B Hutchison
Mar 1, 1982·Journal of Neurochemistry·C J Fowler, K F Tipton
Apr 11, 2018·Journal of Neural Transmission·Keith F Tipton
Dec 1, 1980·The Journal of Pharmacy and Pharmacology·D ParkinsonB A Callingham
Oct 1, 1981·The Journal of Pharmacy and Pharmacology·G A Lyles, B A Callingham
Feb 1, 1984·The Journal of Pharmacy and Pharmacology·C J Fowler, K F Tipton
Sep 1, 1985·The Journal of Pharmacy and Pharmacology·G A Lyles, I Singh
Jul 1, 1983·The Journal of Pharmacy and Pharmacology·C GuffroyM Strolin Benedetti
Apr 1, 1986·The Journal of Pharmacy and Pharmacology·G A Lyles, D R Archer
Aug 15, 1984·Biochemical Pharmacology·G A LylesC M Fitzpatrick
Jan 1, 1983·Biochemical Pharmacology·M S BenedettiC J Fowler
Jun 8, 2021·Mechanisms of Ageing and Development·Cristina SanfilippoMichelino Di Rosa

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