Some forms of cAMP-mediated long-lasting potentiation are associated with release of BDNF and nuclear translocation of phospho-MAP kinase

Neuron
Susan L PattersonE R Kandel

Abstract

Long-lasting forms of synaptic plasticity like the late phase of LTP (L-LTP) typically require an elevation of cAMP, the recruitment of the cAMP-dependent protein kinase (PKA), and ultimately the activation of transcription and translation; some forms also require brain-derived neurotrophic factor (BDNF). Both cAMP and BDNF can activate mitogen-activated protein kinase (MAPK/ERK), which also plays a role in LTP. However, little is known about the mechanisms whereby cAMP, BDNF, and MAPK interact. We find that increases in cAMP can rapidly activate the BDNF receptor TrkB and induce BDNF-dependent long-lasting potentiation at the Schaffer collateral-CA1 synapse in hippocampus. Surprisingly, in these BDNF-dependent forms of potentiation, which are also MAPK dependent, TrkB activation is not critical for the activation of MAPK but instead appears to modulate the subcellular distribution and nuclear translocation of the activated MAPK.

References

Sep 1, 1992·Neuron·J Schlessinger, A Ullrich
Mar 6, 1992·Brain Research·L E Chavez-Noriega, C F Stevens
May 1, 1981·The Journal of Cell Biology·P W GunningE M Shooter
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·M KorteT Bonhoeffer
Jan 1, 1995·Journal of Physiology, Paris·H J Kang, E M Schuman
May 12, 1995·Science·E Kandel, T Abel
Jan 1, 1993·Annual Review of Physiology·C H Bailey, E R Kandel
Oct 4, 1996·The Journal of Biological Chemistry·J D English, J D Sweatt
Oct 7, 1996·The Journal of Comparative Neurology·R H FryerL F Kromer
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·C H BaileyE R Kandel
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·P C SuenI B Black
Aug 1, 1997·The Journal of Biological Chemistry·J D English, J D Sweatt
Nov 14, 1997·Journal of Neurophysiology·C R JarvisJ F MacDonald
Aug 15, 1998·Neuropharmacology·M KorteE Schuman
Dec 18, 1998·Science·H KawasakiA M Graybiel
Apr 15, 1999·Annual Review of Neuroscience·A K McAllisterD C Lo
Jun 18, 1999·Science·L Boulanger, M M Poo

❮ Previous
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Citations

Sep 25, 2009·Experimental Brain Research·Kurt GottmannVolkmar Lessmann
Apr 11, 2012·Cellular and Molecular Neurobiology·Gavin R Owen, Elisabeth Anne Brenner
Apr 19, 2005·The International Journal of Biochemistry & Cell Biology·Bo ZhouJianguo Song
Mar 12, 2004·Progress in Neurobiology·P V Nguyen, N H Woo
Oct 31, 2003·Trends in Neurosciences·Angela L Purcell, Thomas J Carew
Apr 23, 2003·Experimental Cell Research·Angela M Horgan, Philip J S Stork
Mar 12, 2003·Trends in Pharmacological Sciences·Marzia Malcangio, Volkmar Lessmann
Jun 6, 2003·Progress in Neurobiology·Volkmar LessmannMarzia Malcangio
Jun 21, 2002·Trends in Cell Biology·Philip J S Stork, John M Schmitt
Oct 9, 2002·Trends in Biochemical Sciences·Changan Jiang, Erin M Schuman
Apr 15, 2011·Nature·Kristen J BrennandFred H Gage
Sep 2, 2005·Nature Reviews. Neuroscience·J Paige Adams, Serena M Dudek
Jul 22, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Li-Chin Ou, Po-Wu Gean
Sep 14, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christopher Pittenger, Ronald S Duman
Feb 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·Pedro BekinschteinJorge H Medina
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Michael S CohenSamie R Jaffrey
Aug 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Kazuko SakataBai Lu
Apr 19, 2012·Cerebral Cortex·Anais LangloisJean-Luc Gaiarsa
May 13, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Bruno BozonSerge Laroche
May 13, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Christopher Pittenger, Eric R Kandel
May 22, 2004·European Journal of Biochemistry·Charleen T ChuDonald B DeFranco
Jan 23, 2009·Anatomical Science International·Rumi HasegawaFumiaki Nishiyama
Aug 16, 2005·Genes, Brain, and Behavior·P W Vanderklish, G M Edelman
Mar 11, 2010·Science Signaling·Pamela R WestmarkJames S Malter
Jun 4, 2005·BMC Neuroscience·Paul D EtterMani Ramaswami

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