PMID: 9178192May 1, 1997Paper

Some histamine-related compounds interacting with the benzylamine-oxidizing activity of rat white adipocytes

The Journal of Pharmacy and Pharmacology
L RaimondiR Pirisino

Abstract

In rat white adipocytes histamine is oxidized by a semicarbazide-sensitive amine oxidase which has benzylamine or preferential substrate (Bz-SSAO). To determine whether Bz-SSAO could control the extracellular levels of histamine and other histamine-related compounds active in lipid mobilization, a series of histaminergic compounds was screened as possible substrates or inhibitors of Bz-SSAO activity. Histaminergic compounds with imidazolo or thiazolo groups are oxidized by rat white-adipocyte Bz-SSAO whereas S-isothiourea derivatives, with two- or three-carbon-atom alkyl chains between the isothiourea and the N,N-dimethyl residue are, instead, inhibitors of the enzyme. Amtamine has been identified as a selective, high affinity substrate for rat white adipocyte Bz-SSAO. This enzymatic degradation might represent a catabolic pathway for the drug. These results show that the histaminase property of the rat white-adipocyte enzyme Bz-SSAO also extends to other histamine derivatives active at histamine receptors.

References

Feb 1, 1975·The Biochemical Journal·F Buffoni, G Ignesti
Aug 1, 1992·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·L RaimondiF Buffoni
Jun 1, 1995·Pharmacology & Therapeutics·R LeursH Timmerman
Jan 1, 1995·British Journal of Pharmacology·G J SouthanC Thiemermann
Aug 1, 1953·The Biochemical Journal·M DIXON
Aug 1, 1961·The Biochemical Journal·G N WILKINSON

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