PMID: 6169668Jun 15, 1981Paper

Some immunogenic acid biochemical properties of tumor-associated transplantation antigens (TATA) obtained in soluble form or solubilized from two methylcholanthrene-induced sarcomas, Meth A and CI-4

International Journal of Cancer. Journal International Du Cancer
M J Rogers, L W Law

Abstract

The subcellular distribution of the tumor-associated transplantation antigens (TATAs) of two highly immunogenic methylcholanthrene-induced sarcomas, Meth A and CI-4, were compared. Most of the TATA of CI-4 was found in the soluble fraction (cytosol) of the cell while the TATA from Meth A was variably distributed between the membrane and cytosol. The soluble fraction TATAs from both tumors were very immunogenic and their strong immunity could not be influenced by administering antigen in a variety of protocols that altered the immune response in other systems. The soluble fraction and membrane-associated TATAs from both tumors could be specifically bound to liposomes in reconstitution experiments and the antigenicity of all of the TATAs was significantly enhanced when they were incorporated into these artificial membranes.

References

Jan 15, 1979·International Journal of Cancer. Journal International Du Cancer·M J Rogers, L W Law
Oct 1, 1977·Journal of the National Cancer Institute·M J RogersE Appella
Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·V H EngelhardJ L Strominger
Apr 1, 1979·The Journal of Surgical Research·H YamagishiB D Kahan
Nov 15, 1976·International Journal of Cancer. Journal International Du Cancer·M J Embleton
Dec 1, 1977·The Journal of Cell Biology·A HeleniusJ Kartenbeck

❮ Previous
Next ❯

Citations

Jan 1, 1987·Immunology Today·G Parmiani
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·G C DuBoisE Appella
Mar 1, 1982·International Journal of Radiation Oncology, Biology, Physics·J M Brown
Apr 15, 1984·International Journal of Cancer. Journal International Du Cancer·L W Law
Jul 17, 1995·Biochimica Et Biophysica Acta·G F Kersten, D J Crommelin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.