Some intrinsic neurons of the guinea-pig heart contain substance P.

Neuroscience Letters
P Bałuk, G Gabella

Abstract

Whole-mount preparations of the posterior wall of the atria of the guinea pig heart containing intrinsic ganglion cells and nerve plexuses were stained for substance P-like immunoreactivity by the peroxidase-antiperoxidase method. Substance P-like nerve fibres are present as pericellular baskets around most, but not all, of the neuronal cell bodies, and are also found in the connecting nerve bundles, as perivascular nerve plexuses and in the myocardium and pericardium. The majority of ganglion cell bodies are negative for substance P, as reported previously, but we describe for the first time, a small subpopulation of intrinsic neuronal cell bodies which show immunoreactivity for substance P. Therefore, not all cardiac substance P nerves are extrinsic afferent fibres. At present, the physiological role of intrinsic substance P neurones is not clear.

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Citations

Jan 1, 1990·Pharmacology & Therapeutics·M C MioneG Burnstock
Jan 5, 1996·Journal of the Autonomic Nervous System·P A SteeleJ L Morris
Jan 1, 1990·Annals of the New York Academy of Sciences·J Wharton, J M Polak
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Oct 29, 1998·The American Journal of Physiology·G W ThompsonJ A Armour
Jun 24, 2004·European Journal of Pharmacology·Francisco M PintoM Luz Candenas

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