PMID: 6162910Jan 1, 1981Paper

Some kinetic and steady-state properties of sodium channels after removal of inactivation

The Journal of General Physiology
G S Oxford

Abstract

To study the kinetic and steady-state properties of voltage-dependent sodium conductance activation, squid giant axons were perfused internally with either pronase or N-bromoacetamide and voltage clamped. Parameters of activation, tau m and gNa(V), and deactivation, tau Na, were measured and compared with those obtained from control axons under the assumption that gNa oc m3h of the Hodgkin-Huxley scheme. tau m(V) values obtained from the turn-on of INa agree well with control axons and previous determinations by others. tau Na(V) values derived from Na tail currents were also unchanged by pronase treatment and matched fairly well previously published values. tau m(V) obtained from 3 x tau Na(V) were much larger than tau m(V) obtained from INa turn-on at the same potentials, resulting in a discontinuous distribution. Steady-state In (gNa/gNa max - gNa) vs. voltage was not linear and had a limiting logarithmic slope of 5.3 mV/e-fold gNa. Voltage step procedures that induce a second turn-on of INa during various stages of the deactivation (Na tail current) process reveal quasiexponential activation at early stages that becomes increasingly sigmoid as deactivation progresses. For moderate depolarizations, primary and secondary acti...Continue Reading

References

Jun 10, 1975·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·F Bezanilla, C M Armstrong
Nov 1, 1977·The Journal of General Physiology·C M Armstrong, F Bezanilla
Mar 1, 1978·The Journal of General Physiology·G S OxfordT Narahashi
Sep 1, 1978·Biophysical Journal·C L Schauf, J O Bullock
Nov 1, 1976·Quarterly Reviews of Biophysics·L Goldman
Dec 30, 1975·Annals of the New York Academy of Sciences·C M Armstrong
Jan 1, 1976·Cold Spring Harbor Symposia on Quantitative Biology·F Bezanilla, C M Armstrong
Feb 1, 1976·Biophysical Journal·J W Moore, E B Cox
Oct 1, 1973·The Journal of General Physiology·C M ArmstrongE Rojas

❮ Previous
Next ❯

Citations

Jul 1, 1986·Pflügers Archiv : European journal of physiology·H Meves, N Rubly
Jul 1, 1984·Pflügers Archiv : European journal of physiology·H P VijverbergM Lazdunski
Jan 1, 1986·Pflügers Archiv : European journal of physiology·G N MozhayevaE D Nosyreva
Jan 1, 1985·The Journal of Membrane Biology·F Bezanilla
Dec 1, 1990·The Journal of Membrane Biology·R Hahin
Jun 9, 1987·Brain Research·C L Schauf
Jan 1, 1985·Progress in Neurobiology·D Yamamoto
Nov 25, 2004·Progress in Biophysics and Molecular Biology·John R Clay
May 1, 1983·Biophysical Journal·J R Clay, L J DeFelice
Jul 1, 1987·Biophysical Journal·M F SheetsH A Fozzard
May 30, 2001·Progress in Biophysics and Molecular Biology·D Fedida, J C Hesketh
Feb 1, 1994·The Journal of General Physiology·W N ZagottaR W Aldrich
Aug 5, 1998·The Journal of General Physiology·B M RodríguezF Bezanilla
Oct 17, 2007·The Journal of General Physiology·Sudha ChakrapaniEduardo Perozo
Feb 13, 2013·The Journal of General Physiology·Carlos GonzalezH Peter Larsson
Mar 1, 1982·The Journal of General Physiology·J Patlak, R Horn
Apr 1, 1982·The Journal of General Physiology·J M Dubois, M F Schneider
Jun 1, 1982·The Journal of General Physiology·W F Gilly, C M Armstrong
Jul 1, 1982·The Journal of General Physiology·L Goldman, J L Kenyon
Jan 1, 1985·The Journal of General Physiology·J R StimersR E Taylor
Apr 1, 1985·The Journal of General Physiology·M M White, F Bezanilla
May 1, 1985·The Journal of General Physiology·P Forscher, G S Oxford
Jan 1, 1986·The Journal of General Physiology·J B Sutro
Feb 1, 1986·The Journal of General Physiology·J B Patlak, M Ortiz
Feb 1, 1987·The Journal of General Physiology·T Gonoi, B Hille
Aug 1, 1989·The Journal of General Physiology·J B Patlak, M Ortiz
Mar 1, 1991·The Journal of General Physiology·J Tanguy, J Z Yeh
Jun 12, 2008·Journal of the Royal Society, Interface·John R ClayDaniel B Forger
Jun 9, 1998·Annals of the New York Academy of Sciences·R L Ruff
Sep 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Robert K Adair
Jan 1, 1996·Neuropharmacology·B M Rodríguez, F Bezanilla
Dec 1, 1987·Experientia·H A FozzardM F Sheets
Apr 1, 1983·The Journal of General Physiology·K G Beam, P L Donaldson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.