Some limitations of a proposed linear model for antimicrobial risk management

Risk Analysis : an Official Publication of the Society for Risk Analysis
Louis Anthony Tony Cox

Abstract

The FDA Center for Veterinary Medicine (CVM) (Bartholomew et al., 2005) recently proposed an approach to risk management based on the linear modeling framework: Risk = K x Exposure. They suggest that, once K has been estimated from historical data, it can be used to predict how limiting future exposure will reduce future risk. They illustrate the approach for fluoroquinolone-resistant campylobacter in chicken. However, despite its appealing simplicity, the proposed approach confuses a possibly meaningless descriptive statistical ratio with a valid predictive causal relation. In general, the historical ratio K = (Risk/Exposure) may not predict how changing future exposures will affect future risks, and hence it does not necessarily provide an appropriate guide to current risk management actions. We identify several limitations of the proposed framework, including omission of frequency and severity of human health harm in quantifying "Risk" and omission of microbial load from "Exposure." Finally, we show that an extended linear modeling approach that considers impacts of changing animal antibiotic use on susceptible as well as on resistant bacteria is consistent with the conclusion that reducing "Exposure" can greatly increase "R...Continue Reading

References

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Apr 20, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cindy R FriedmanUNKNOWN Emerging Infections Program FoodNet Working Group
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Mar 25, 2005·Risk Analysis : an Official Publication of the Society for Risk Analysis·Mary J BartholomewCurtis C Travis

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Citations

May 18, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Louis Anthony Cox
Jul 19, 2005·Risk Analysis : an Official Publication of the Society for Risk Analysis·Louis Anthony Tony CoxWilliam Huber
Mar 17, 2007·Risk Analysis : an Official Publication of the Society for Risk Analysis·Louis Anthony Tony Cox
Jul 23, 2008·Risk Analysis : an Official Publication of the Society for Risk Analysis·H Scott Hurd, Sasidhar Malladi
May 22, 2007·Risk Analysis : an Official Publication of the Society for Risk Analysis·Louis Anthony Cox, Douglas A Popken
Nov 3, 2009·Risk Analysis : an Official Publication of the Society for Risk Analysis·Louis Anthony Tony Cox
Feb 9, 2010·Risk Analysis : an Official Publication of the Society for Risk Analysis·Louis Anthony Tony Cox, Douglas A Popken
Feb 9, 2010·Risk Analysis : an Official Publication of the Society for Risk Analysis·Jane HellerDominic J Mellor
Jul 26, 2006·Avian Diseases·Randall S Singer, Charles L Hofacre

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