Some mechanisms underlying actions of ketamine on electromechanical coupling in skeletal muscle

Journal of Neuroscience Research
J Marwaha

Abstract

The effects on excitation contraction coupling (ECC) of ketamine (a dissociative general anesthetic) were investigated using the sartorius muscle of the frog. Extracellular studies revealed that ketamine depressed action potential production in a concentration-dependent manner. Ketamine decreased both the conduction velocity and the compound action potential while concomitantly increasing the threshold current. Intracellular studies showed that ketamine caused a slight non-significant decrease in the membrane potential and also decreased the threshold potential (mechanical threshold). Ketamine (1.5 X 10(-4) M and 3.0 X 10(-4) M) initially potentiated and then blocked the twitch response elicited by direct muscle stimulation. Both of these effects were statistically different from control values. These findings suggest that ketamine alters action potential production in frog skeletal muscle. This property of ketamine contributes in part to the disruption of ECC observed with this drug. The results suggest the ketamine probably interferes with calcium binding, its release and/or its fluxes which may contribute to the intial potentiation and subsequent depression of twitch tension.

References

Jun 1, 1978·Canadian Journal of Physiology and Pharmacology·G B Frank, J Marwaha
Dec 1, 1975·Anesthesiology·B I DiamondH C Sabelli
Oct 1, 1973·Anesthesiology·P A Radnay, R P Badola
Nov 5, 1956·Acta Physiologica Scandinavica·S THESLEFF
May 1, 1965·Clinical Pharmacology and Therapeutics·E F DOMINOG CORSSEN
Aug 1, 1951·Journal of Cellular Physiology·M C BERWICK

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Citations

Mar 1, 1989·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D L Reich, G Silvay
Aug 6, 2000·British Journal of Anaesthesia·P M Hopkins
Sep 14, 1999·The American Journal of Physiology·B M Lapointe, C H Côté

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