PMID: 20650160Dec 1, 1995Paper

Some milestones in in vitro organ Toxicity Assessment. The Kidney as a Case Study

Toxicology in Vitro : an International Journal Published in Association with BIBRA
J P MorinC Monteil

Abstract

The expression of target organ toxicity ranges from subtle abnormalities of cellular organelles to permanent loss of organ function. The selective targeting of chemicals for discrete regions and cell types of a given organ is frequently due (besides some pharmacodynamic mechanisms) to the fact that target cells may express unique biochemical or functional characteristics predisposing them to chemically induced injury. In vitro models commonly used in target organ toxicity tests include perfused organ preparations, isolated tissue preparations, single-cell suspensions and tissue culture systems. Although these systems have proved their usefulness for acute toxicity tests, there is still a great need for in vitro models to be used for chronic toxicity tests. Among the systems listed above, the single-cell culture technique may be adapted to long-term study requirements. The example of kidney proximal tubules is taken to illustrate the necessity for extensive characterization of the actual capacities of the models in term of phenotypic profiling, energy status, drug detoxication activities, specific transport systems and organ-specific differentiated functions. LLC-PK1, LLC-RK1, NRK and OK cell lines are compared with primary cult...Continue Reading

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Citations

Dec 1, 1995·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M Balls
Dec 1, 1998·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D K ObatomiP H Bach

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