Aug 1, 1976

Some minimal effects of bile acid on canine gastric mucosa in Heidenhain pouches

The American Journal of Digestive Diseases
W D ReesR G Newcombe

Abstract

The gastric mucosa in four canine Heidenhain pouches was damaged with sodium taurocholate in a concentration which was just sufficient in each dog to produce consistent changes. Solutions were placed in the pouches and changes in the volume, concentrations, and fluxes of both hydrogen ion and sodium ion were measured before and during exposure to taurocholate. Changes which occurred with taurocholate were compared with control periods; taurocholate caused a relative increase in volume of 1 ml and approximately a fourfold increase in the hydrogen ion and sodium ion concentrations and the sodium ion flux. Changes in the hydrogen ion flux were smaller and, in some experiments, insignificant. Change in the hydrogen ion flux is less sensitive than the other parameters as an indicator of minimal mucosal damage.

  • References6
  • Citations1

Citations

Mentioned in this Paper

Bile Acid Measurement
Mucositis
Structure of Pyloric Gland
Body Surface Area Formula for Dogs
Sodium Cation
Sodium
Taurocholic Acid, (7 beta)-Isomer
Gastric Mucosa
Dog family
Taurocholic Acid, Monosodium Salt

About this Paper

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