Some neonatal risk factors for adult pulmonary arterial hypertension remain unknown

Acta Paediatrica
Estelle NaumburgLars Söderström

Abstract

Pulmonary hypertension has been linked to premature birth, chronic lung disease, bronchopulmonary dysplasia and congenital heart disease. This national population-based registry study assessed the risk of adult pulmonary hypertension following premature birth, adjusted for known risk factors. We focused on adults in the Swedish Pulmonary Arterial Hypertension Registry, who were born prematurely, and controls randomly selected from the Swedish medical birth register and matched to each case by birth year and delivery hospital. Information on perinatal factors was also retrieved from the medical birth register. Conditional multiple logistic regression was used to evaluate the association between premature birth and adult pulmonary hypertension, taking into account the potential confounding factors. The study population comprised 427 adults born between 1973 and 1996, with 61 cases and 366 controls. Adult pulmonary hypertension was associated with premature birth, with an odds ratio of 3.08 and 95% confidence interval of 1.21-7.87. The association did not alter after adjusting for potential confounders. By adjusting for factors linked to adult pulmonary hypertension, namely congenital heart defects, pulmonary diseases and prematur...Continue Reading

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Citations

Jan 28, 2017·American Journal of Respiratory Cell and Molecular Biology·Kara N GossMarlowe W Eldridge
Aug 2, 2018·The Journal of Physiology·Kara Goss
Jun 27, 2018·American Journal of Respiratory and Critical Care Medicine·Kara N GossMarlowe W Eldridge
Mar 19, 2019·Pulmonary Circulation·Kara N GossTim Lahm
Jul 7, 2017·Pulmonary Circulation·Kara N GossSteven H Abman
Nov 2, 2016·Pediatric Pulmonology·Estelle NaumburgInge Axelsson
Aug 20, 2019·BMC Pediatrics·Estelle Naumburg, Lars Söderström

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