PMID: 8585756Sep 1, 1995Paper

Some nucleoside analogs with anti-human immunodeficiency virus activity inhibit replication of Epstein-Barr virus

Antiviral Research
E C MarJung Chung Lin

Abstract

The effects of (+)-beta-D-dioxolane-cytosine ((+)-D-beta-DOC), (-)-beta-L-dioxolane-cytosine ((-)-L-beta-DOC), (+)-beta-D-oxathiolane-cytosine ((+)-D-beta-OTC), (-)-beta-L-oxathiolane-cytosine ((-)-L-beta-OTC, or 3TC), 3'-azido-2',3'-dideoxy-5-methyl-cytidine (5-Me-AZDC), and 3'-azido-2',3'-dideoxyuridine (AZDU) on Epstein-Barr virus (EBV) DNA replication in vitro were tested in P3HR-1 cells. Two anti-EBV drugs, 3'-azido-3'-deoxythymidine (AZT) and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG, or ganciclovir), were used as positive controls. The inhibitory effects on EBV DNA synthesis were quantified by membrane filter and Southern blot hybridizations with an EBV-specific probe BamHI-W fragment. The 50% effective doses (ED50) for EBV DNA replication were 0.15, 0.83, 1.5, 8.3, 14, and 7.7 microM for DHPG, (-)-L-beta-DOC, (+)-D-beta-DOC, (+)-D-beta-OTC, (-)-L-beta-OTC, and AZT, respectively. In contrast, 5-Me-AZDC and AZDU were not effective at concentrations as high as 30 microM. These results indicated that both (-)-L-beta-DOC and (+)-D-beta-DOC were more potent than AZT, which has previously been shown to have anti-EBV activity. (-)-L-beta-DOC and (+)-D-beta-DOC have also been previously demonstrated to suppress the infectiv...Continue Reading

References

May 29, 1992·Journal of Medicinal Chemistry·H O KimC K Chu
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S L DoongY C Cheng
Jan 1, 1990·Annals of the New York Academy of Sciences·R F SchinaziH M McClure
Jan 1, 1990·AIDS·J A NelsonC A Wiley
Jan 1, 1989·Journal of Medical Virology·V TozziO Strannegård
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M G DavisE S Huang
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S KenneyJ Pagano
Jun 1, 1988·Journal of Medical Virology·M L SmileyE S Huang
Jan 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·G HenleV Diehl
Sep 18, 1982·Lancet·J L ZieglerK Yamamoto
Apr 1, 1981·AJR. American Journal of Roentgenology·A G KrudyR Spiegel
Sep 24, 1981·The New England Journal of Medicine·J L Ziegler

❮ Previous
Next ❯

Citations

Oct 24, 2001·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G Mathé
Jul 17, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·T BaldewegB G Gazzard
Jun 15, 2007·Hematology·R Swords, F Giles
Apr 1, 2004·Expert Opinion on Therapeutic Patents·Astrid MeerbachPeter Wutzler
Jul 4, 2007·Hematology·Ronan SwordsFrancis Giles
Mar 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Francis J GilesHagop M Kantarjian
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Francis J GilesHagop M Kantarjian
Jan 6, 1999·Antiviral Chemistry & Chemotherapy·A MeerbachJ Neyts
Feb 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F J GilesH M Kantarjian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.