PMID: 7336434Jan 1, 1981Paper

Some observations on dimethylformamide hepatotoxicity

Toxicology
I LundbergT Kronevi

Abstract

Dimethylformamide (DMF) and its biotransformation products monomethylformamide (MMF) and formamide (F) were administered intraperitoneally to rats. Serum levels of sorbitol dehydrogenase (SDH) were studied at 3 h intervals from 9 h to 30 h after administration. Liver histology at 12, 21 and 30 h proved elevated SDH levels to be an indication of liver necrosis. DMF 479 mg/kg produced elevated enzyme levels at 27 h and 30 h while half the dose, 240 mg/kg, produced elevated levels from 15 h onwards. MMF 387 mg/kg produced elevated SDH levels at all times studied. F did not give elevated levels at any time. DMF (479 mg/kg) and MMF (387 mg/kg) administered simultaneously produced elevated SDH levels from 24 h onwards. These findings suggest that DMF hepatotoxicity is mediated by a degradation product of MMF and that DMF delays the hepatotoxic effect induced by MMF.

References

Mar 1, 1963·American Industrial Hygiene Association Journal·J W CLAYTONG W SCHEPERS

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Citations

Oct 1, 1990·Journal of Applied Toxicology : JAT·E Hansen, O Meyer
Jan 1, 1992·International Archives of Occupational and Environmental Health·J Mráz, H Nohová
Jan 1, 1988·Archives of Toxicology·K Tulip, J A Timbrell
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Jan 8, 1999·Toxicology and Applied Pharmacology·M J TwinerS J Dixon

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