PMID: 6014Feb 1, 1976

Some observations on the NADP+-linked oxidation of methylglyoxal catalysed by 2-Oxoaldehyde dehydrogenase

The Biochemical Journal
J Dunkerton, S P James

Abstract

In the oxidation of methylglyoxal by 2-oxoaldehyde dehydrogenase, the apparent Km value for NADP+ was about 2.5 times lower than the corresponding Km for NAD+; the apparent Km values for methylglyoxal and for the amine activator L-2-aminopropan-1-ol, with NADP+ as cofactor, were also different from those obtained with NAD+. In the presence of NADP+, the enzyme was not activated by P1, in contrast with the activation of the enzyme when NAD+ was used. The significance of the results is discussed.

Citations

Jun 7, 2008·Drug Metabolism and Drug Interactions·D L Vander Jagt

Related Concepts

Aldehyde Oxidoreductases
Aldehydes
NADP
Oxidation-Reduction
Oxopropanal
Dall Sheep

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