PMID: 632224Feb 1, 1978Paper

Some observations on the nature of reactive groups involved in reversal of mycobacillin inhibition by sterols and lipids

The Journal of Antibiotics
S Mukherjee, S K Bose

Abstract

Antifungal action of di- and triacetyl derivatives of mycobacillin is not antagonised by cholesterol or lecithin which antagonise the action of its heptamethyl derivative. Considering the reactive groups of mycobacillin, the antagonism may involve the tyrosine hydroxyl groups of the antibiotic and the 3-hydroxyl group of cholesterol of the oleic acid component of lecithin having unsaturation at the 9:10 position with cis-configuration.

Related Concepts

Antibiotics, Antifungal
Epicholesterol
Isomerism
Mycobacillin
Oleic Acids
Phosphatidylcholines
Structure-Activity Relationship

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An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

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An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.