PMID: 4905994Nov 1, 1969Paper

Some observations on the near ultraviolet circular dichroism of tRNA from E. coli

Proceedings of the National Academy of Sciences of the United States of America
J F Scott, P Schofield


The circular dichroism arising from 4-thiouridine residues in E. coli transfer RNA has been studied under conditions in which the secondary and tertiary structure of the macromolecule is either intact or totally disrupted. Studies on both unfractionated tRNA and on highly purified species of methionine-, valine-, and lysine-specific tRNA suggest that the circular dichroism of the 4-thiouridine residue is highly sensitive to its local environment in the macro-molecule and reveal interesting differences between these purified species. A new chromophore, resembling 4-thiouridine in some respects but showing distinctive chemical and optical properties, has been detected. The implications of these results on model-building studies of tRNA are discussed.


May 25, 1966·Biochemical and Biophysical Research Communications·L Katz, S Penman
Apr 20, 1968·Nature·S K DubeS Cory
Apr 19, 1969·Nature·M Yaniv, B G Barrell
May 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·J A CarbonD S Jones
May 14, 1967·Journal of Molecular Biology·P K SarkarJ T Yang
Jun 1, 1968·Biopolymers·J H StraussR L Sinsheimer
Feb 12, 1969·Journal of the American Chemical Society·D W MilesH Eyring


Jul 1, 1976·Nucleic Acids Research·K WatanabeS Nishimura
May 10, 1972·Biochimica Et Biophysica Acta·J E Strickland, K B Jacobson
May 22, 1970·Biochemical and Biophysical Research Communications·R I Cotter, W B Gratzer
Mar 5, 1971·Biochemical and Biophysical Research Communications·Y Lalyre, E B Tirchener

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